Pub. Date : 2002 May
PMID : 11950789
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Because expression of CYP3A family members can be induced by activation of another member of the nuclear receptor superfamily, the pregnane X receptor (PXR), we examined the ability of DHEA to activate PXR. | Dehydroepiandrosterone | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 2 | In transient transfection assays, DHEA and its metabolites androst-5-ene-3beta,17beta-diol (ADIOL), androst-5-ene-3,17-dione, and androst-4-ene-3,17-dione were activators of PXR. | Dehydroepiandrosterone | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 3 | Maximal induction of a PXR-responsive reporter gene of approximately 3-fold was observed at concentrations of 50 to 100 microM, indicating that these steroids are relatively weak activators of PXR. | Steroids | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 4 | Maximal induction of a PXR-responsive reporter gene of approximately 3-fold was observed at concentrations of 50 to 100 microM, indicating that these steroids are relatively weak activators of PXR. | Steroids | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 5 | Human and murine PXR exhibited different specificities for DHEA and its metabolites. | Dehydroepiandrosterone | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 6 | Results of these studies suggest that the induction of rodent CYP3A expression upon treatment with high doses of DHEA occurs through activation of PXR. | Dehydroepiandrosterone | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |