Title : Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes.

Pub. Date : 2004 Sep

PMID : 15340055






3 Functional Relationships(s)
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1 In contrast, CAR and PXR, acting as corepressors, downregulated FOXO1-mediated transcription in the presence of their activators, such as 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and pregnenolone 16alpha-carbonitrile, respectively. 1,4-bis(2-(3,5-dichloropyridyloxy))benzene nuclear receptor subfamily 1, group I, member 2 Mus musculus
2 In contrast, CAR and PXR, acting as corepressors, downregulated FOXO1-mediated transcription in the presence of their activators, such as 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and pregnenolone 16alpha-carbonitrile, respectively. 1,4-bis(2-(3,5-dichloropyridyloxy))benzene nuclear receptor subfamily 1, group I, member 2 Mus musculus
3 In contrast, CAR and PXR, acting as corepressors, downregulated FOXO1-mediated transcription in the presence of their activators, such as 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) and pregnenolone 16alpha-carbonitrile, respectively. Pregnenolone Carbonitrile nuclear receptor subfamily 1, group I, member 2 Mus musculus