Pub. Date : 2005 Feb 8
PMID : 15684063
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic nuclear receptors that coordinate protective hepatic responses to potentially toxic stimuli, including bile acids. | Bile Acids and Salts | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 2 | The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic nuclear receptors that coordinate protective hepatic responses to potentially toxic stimuli, including bile acids. | Bile Acids and Salts | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 3 | Hepatic damage from bile acid accumulation was increased in both CAR knockout (CARKO) and PXR knockout mice, but bile acid concentrations were lower in CARKO mice. | Bile Acids and Salts | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 4 | High-density lipoprotein (HDL) cholesterol was elevated in CARKO mice, and serum total cholesterol increased less in CARKO or PXR knockout mice than WT mice after BDL. | Cholesterol | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 5 | These results demonstrate that CAR and PXR influence cholesterol metabolism and bile acid synthesis, as well as multiple detoxification pathways, and suggest their potential role as therapeutic targets for the treatment of cholestasis and lipid disorders. | Cholesterol | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 6 | These results demonstrate that CAR and PXR influence cholesterol metabolism and bile acid synthesis, as well as multiple detoxification pathways, and suggest their potential role as therapeutic targets for the treatment of cholestasis and lipid disorders. | Bile Acids and Salts | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |