Pub. Date : 2003 Jan 7
PMID : 12509506
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. | Bile Acids and Salts | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 2 | In parallel, the induction of Cyp3a11 observed in these mice is reversed, suggesting that bile acid intermediates serve as PXR activators. | Bile Acids and Salts | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 3 | Taken together, these results reveal the existence of a feedforward regulatory loop by which potentially toxic bile acid intermediates activate PXR and induce their own metabolism. | Bile Acids and Salts | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |