microcystin






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1 1646647 Differing effects of the protein phosphatase inhibitors okadaic acid and microcystin on translation in reticulocyte lysates. Biochim Biophys Acta 1991 Jun 7 2
2 1847622 Plant protein phosphatases. Subcellular distribution, detection of protein phosphatase 2C and identification of protein phosphatase 2A as the major quinate dehydrogenase phosphatase. Biochem J 1991 Feb 1 2
3 7556599 The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1. FEBS Lett 1995 Sep 11 6
4 7684044 Transforming growth factor-beta 1 stimulates macrophage urokinase expression and release of matrix-bound basic fibroblast growth factor. J Cell Physiol 1993 Jun 2
5 7720853 Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography. FEBS Lett 1995 Apr 3 1
6 7988718 Purification of type 1 protein (serine/threonine) phosphatases by microcystin-Sepharose affinity chromatography. FEBS Lett 1994 Dec 12 3
7 8145146 Opposite effects of phosphatase inhibitors on L-type calcium and delayed rectifier currents in frog cardiac myocytes. J Physiol 1993 Dec 1
8 8384557 PPX, a novel protein serine/threonine phosphatase localized to centrosomes. EMBO J 1993 Mar 1
9 8387296 Purified mammalian HSP-70 KDA activates phosphoprotein phosphatases in vitro. Biochem Biophys Res Commun 1993 Apr 30 1
10 8799831 Evidence that the endogenous histone H1 phosphatase in HeLa mitotic chromosomes is protein phosphatase 1, not protein phosphatase 2A. J Cell Sci 1996 Jun 2
11 8910475 Identification of protein phosphatase-1-binding proteins by microcystin-biotin affinity chromatography. J Biol Chem 1996 Nov 8 2
12 9214467 Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport. Hepatology 1997 Jul 1
13 9461514 Identification and localization of myosin phosphatase in human platelets. Biochem J 1998 Feb 15 1
14 9575170 Inhibitors of protein phosphatase 1 and 2A differentially regulate the expression of inducible nitric-oxide synthase in rat astrocytes and macrophages. J Biol Chem 1998 May 15 2
15 9657521 The unimportance of being (protein kinase C) epsilon. FASEB J 1998 Jul 2
16 9660883 Regulation of Ca2+-dependent Cl- conductance in a human colonic epithelial cell line (T84): cross-talk between Ins(3,4,5,6)P4 and protein phosphatases. J Physiol 1998 Aug 1 1
17 9864372 Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice. J Cell Biol 1998 Dec 28 2
18 9873003 Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A. J Biol Chem 1999 Jan 8 1
19 10206668 Effects of microcystins on phosphorylase-a binding to phosphatase-2A: kinetic analysis by surface plasmon resonance biosensor. Biochim Biophys Acta 1999 Mar 14 1
20 10591628 Protein phosphatases PP1 and PP2A are located in distinct positions in the Chlamydomonas flagellar axoneme. J Cell Sci 2000 Jan 1
21 10617120 Long-term depression in the hippocampus in vivo is associated with protein phosphatase-dependent alterations in extracellular signal-regulated kinase. J Neurochem 2000 Jan 1
22 10712589 A diminished activation capacity of the interferon-inducible protein kinase PKR in human T lymphocytes. Eur J Biochem 2000 Mar 1
23 10749866 Phosphorylation of the nuclear transport machinery down-regulates nuclear protein import in vitro. J Biol Chem 2000 Jun 9 1
24 10766855 Reversible phosphorylation of the signal transduction complex in Drosophila photoreceptors. J Biol Chem 2000 Apr 21 1
25 11011032 Inhibitors of tyrosine phosphatases block angiotensin II inhibition of Na(+) pump. Eur J Pharmacol 2000 Oct 6 1
26 11320080 Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2. J Biol Chem 2001 Jun 29 1
27 11397554 Microcystin-induced down-regulation of lymphocyte functions through reduced IL-2 mRNA stability. Toxicol Lett 2001 May 31 3
28 11821394 The atrial natriuretic peptide receptor (NPR-A/GC-A) is dephosphorylated by distinct microcystin-sensitive and magnesium-dependent protein phosphatases. J Biol Chem 2002 May 3 2
29 12051739 PP1 phosphatase is involved in Bcl-2 dephosphorylation after prolonged mitotic arrest induced by paclitaxel. Biochem Biophys Res Commun 2002 Jun 7 1
30 12411203 [The expression of bcl-2 and bax genes during microcystin induced liver tumorigenesis]. Zhonghua Yu Fang Yi Xue Za Zhi 2002 Jul 5
31 12444072 Sperm PP1gamma2 is regulated by a homologue of the yeast protein phosphatase binding protein sds22. Biol Reprod 2002 Dec 1
32 12555814 Detection of multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 in rat liver nuclei. Biochem Cell Biol 2002 1
33 14611854 Linearized and truncated microcystin analogues as inhibitors of protein phosphatases 1 and 2A. Bioorg Med Chem Lett 2003 Sep 1 1
34 14611855 Microcystin analogues comprised only of Adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors. Bioorg Med Chem Lett 2003 Sep 1 3
35 15051402 Effects of microcystins on the growth and the activity of superoxide dismutase and peroxidase of rape (Brassica napus L.) and rice (Oryza sativa L.). Toxicon 2004 Mar 15 1
36 15342961 Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation. Toxicol Sci 2004 Dec 3
37 15774489 Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade. Carcinogenesis 2005 Jul 7
38 16201970 Integrin-linked kinase is responsible for Ca2+-independent myosin diphosphorylation and contraction of vascular smooth muscle. Biochem J 2005 Dec 15 2
39 16343532 Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins. J Mol Biol 2006 Feb 10 1
40 16684551 Comparison of protein phosphatase inhibition activities and mouse toxicities of microcystins. Toxicon 2006 Jun 1 6
41 17163649 Structural characterization of in vitro and in vivo intermediates on the loading module of microcystin synthetase. ACS Chem Biol 2006 Mar 17 1
42 17198718 The organic anion transport polypeptide 1d1 (Oatp1d1) mediates hepatocellular uptake of phalloidin and microcystin into skate liver. Toxicol Appl Pharmacol 2007 Feb 1 1
43 17308056 Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells. Mol Cancer Ther 2007 Feb 3
44 17656444 Characterization of protein kinase pathways responsible for Ca2+ sensitization in rat ileal longitudinal smooth muscle. Am J Physiol Gastrointest Liver Physiol 2007 Oct 8
45 19027771 Oatp-associated uptake and toxicity of microcystins in primary murine whole brain cells. Toxicol Appl Pharmacol 2009 Jan 15 2
46 19041662 In vivo study on the effects of microcystin extracts on the expression profiles of proto-oncogenes (c-fos, c-jun and c-myc) in liver, kidney and testis of male Wistar rats injected i.v. with toxins. Toxicon 2009 Jan 2
47 19151163 First identification of the hepatotoxic microcystins in the serum of a chronically exposed human population together with indication of hepatocellular damage. Toxicol Sci 2009 Mar 1
48 19374427 Electrolyte-induced ionization suppression and microcystin toxins: ammonium formate suppresses sodium replacement ions and enhances protiated and ammoniated ions for improved specificity in quantitative LC-MS-MS. Anal Chem 2009 May 15 1
49 19501114 The effect of structural variation in 21 microcystins on their inhibition of PP2A and the effect of replacing cys269 with glycine. Toxicon 2009 Sep 15 4
50 19531490 Phosphorylation-dependent autoinhibition of myosin light chain phosphatase accounts for Ca2+ sensitization force of smooth muscle contraction. J Biol Chem 2009 Aug 7 5