Title : The atrial natriuretic peptide receptor (NPR-A/GC-A) is dephosphorylated by distinct microcystin-sensitive and magnesium-dependent protein phosphatases.

Pub. Date : 2002 May 3

PMID : 11821394






2 Functional Relationships(s)
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1 The serine/threonine protein phosphatase inhibitor, microcystin, inhibited the desensitization of NPR-A in membrane guanylyl cyclase assays in the absence of magnesium. microcystin natriuretic peptide receptor 1 Mus musculus
2 The desensitization required changes in the phosphorylation state of NPR-A because the guanylyl cyclase activity of a receptor variant containing glutamate substitutions at all six phosphorylation sites was unaffected by MgCl(2), EDTA, or microcystin. microcystin natriuretic peptide receptor 1 Mus musculus