Title : Comparison of protein phosphatase inhibition activities and mouse toxicities of microcystins.

Pub. Date : 2006 Jun 1

PMID : 16684551






6 Functional Relationships(s)
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1 By comparing the LD(50) values of the mouse toxicity assay and IC(50) values of the PP-1 and PP-2A inhibition assay of eight MCs using linear regression, it is evident that the MC-induced toxicity is much more related to the inhibition of PP-2A than PP-1, which suggests that PP-2A inhibition may play a major role in the MC-induced mouse toxicity. microcystin protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus
2 By comparing the LD(50) values of the mouse toxicity assay and IC(50) values of the PP-1 and PP-2A inhibition assay of eight MCs using linear regression, it is evident that the MC-induced toxicity is much more related to the inhibition of PP-2A than PP-1, which suggests that PP-2A inhibition may play a major role in the MC-induced mouse toxicity. microcystin protein phosphatase 1 catalytic subunit gamma Mus musculus
3 By comparing the LD(50) values of the mouse toxicity assay and IC(50) values of the PP-1 and PP-2A inhibition assay of eight MCs using linear regression, it is evident that the MC-induced toxicity is much more related to the inhibition of PP-2A than PP-1, which suggests that PP-2A inhibition may play a major role in the MC-induced mouse toxicity. microcystin protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus
4 By comparing the LD(50) values of the mouse toxicity assay and IC(50) values of the PP-1 and PP-2A inhibition assay of eight MCs using linear regression, it is evident that the MC-induced toxicity is much more related to the inhibition of PP-2A than PP-1, which suggests that PP-2A inhibition may play a major role in the MC-induced mouse toxicity. microcystin protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus
5 By comparing the LD(50) values of the mouse toxicity assay and IC(50) values of the PP-1 and PP-2A inhibition assay of eight MCs using linear regression, it is evident that the MC-induced toxicity is much more related to the inhibition of PP-2A than PP-1, which suggests that PP-2A inhibition may play a major role in the MC-induced mouse toxicity. microcystin protein phosphatase 1 catalytic subunit gamma Mus musculus
6 By comparing the LD(50) values of the mouse toxicity assay and IC(50) values of the PP-1 and PP-2A inhibition assay of eight MCs using linear regression, it is evident that the MC-induced toxicity is much more related to the inhibition of PP-2A than PP-1, which suggests that PP-2A inhibition may play a major role in the MC-induced mouse toxicity. microcystin protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform Mus musculus