| 1 |
35487360 | Critical target identification and human health risk ranking of metal ions based on mechanism-driven modeling. | 2022 Aug |
2 |
| 2 |
35488931 | A role for bioinorganic chemistry in the reactivation of mutant p53 in cancer. | 2022 Apr 30 |
3 |
| 3 |
33238842 | Dual Modulators of p53 and Cyclin D in ER Alpha Signaling by Albumin Nanovectors Bearing Zinc Chaperones for ER-positive Breast Cancer Therapy. | 2021 |
6 |
| 4 |
31379409 | Sublethal treatment with plasma-activated medium induces senescence-like growth arrest of A549 cells: involvement of intracellular mobile zinc. | 2019 Jul |
3 |
| 5 |
32042215 | Zinc Oxide nanoparticles induce oxidative and proteotoxic stress in ovarian cancer cells and trigger apoptosis Independent of p53-mutation status. | 2019 Sep |
1 |
| 6 |
30230059 | Multifunctional Compounds for Activation of the p53-Y220C Mutant in Cancer. | 2018 Dec 3 |
2 |
| 7 |
27195669 | Developing a Gene Biomarker at the Tipping Point of Adaptive and Adverse Responses in Human Bronchial Epithelial Cells. | 2016 |
1 |
| 8 |
27567443 | Zinc enhances CDKN2A, pRb1 expression and regulates functional apoptosis via upregulation of p53 and p21 expression in human breast cancer MCF-7 cell. | 2016 Oct |
1 |
| 9 |
25710967 | Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore. | 2015 May |
2 |
| 10 |
26205328 | Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer. | 2015 Nov |
4 |
| 11 |
26297485 | The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells. | 2015 Aug 22 |
2 |
| 12 |
26314369 | Zn(II)-curc targets p53 in thyroid cancer cells. | 2015 Oct |
5 |
| 13 |
26493598 | High metallothionein predicts poor survival in glioblastoma multiforme. | 2015 Oct 22 |
1 |
| 14 |
24874727 | Degradation of mutant p53H175 protein by Zn(II) through autophagy. | 2014 May 29 |
2 |
| 15 |
25002230 | Design and synthesis of 8-hydroxyquinoline-based radioprotective agents. | 2014 Aug 1 |
1 |
| 16 |
22803791 | The substitutions G245C and G245D in the Zn(2+)-binding pocket of the p53 protein result in differences of conformational flexibility of the DNA-binding domain. | 2013 |
17 |
| 17 |
23401182 | The effect of zinc and the role of p53 in copper-induced cellular stress responses. | 2013 Jul |
5 |
| 18 |
24280450 | Evaluation of zinc (II) chelators for inhibiting p53-mediated apoptosis. | 2013 Dec |
3 |
| 19 |
21935692 | Zinc deficiency or excess within the physiological range increases genome instability and cytotoxicity, respectively, in human oral keratinocyte cells. | 2012 Apr |
1 |
| 20 |
22427690 | Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature. | 2012 Jul 1 |
3 |
| 21 |
22766626 | Effect of zinc(II) ions on the expression of pro- and anti-apoptotic factors in high-grade prostate carcinoma cells. | 2012 Sep |
1 |
| 22 |
22869710 | First-order rate-determining aggregation mechanism of p53 and its implications. | 2012 Aug 21 |
2 |
| 23 |
23652223 | Rising environmental cadmium levels in developing countries: threat to genome stability and health. | 2012 Dec 18 |
2 |
| 24 |
21076775 | Predicting the coordination geometry for Mg2+ in the p53 DNA-binding domain: insights from computational studies. | 2011 Jan 21 |
2 |
| 25 |
21660051 | Intracellular zinc release-activated ERK-dependent GSK-3β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury. | 2011 Oct |
2 |
| 26 |
21780454 | Identification of p53 gene by using CdSe/ZnS conjugation and hybridization. | 2011 May |
1 |
| 27 |
20660093 | Enhanced Gadd45 expression and delayed G2/M progression are p53-dependent in zinc-supplemented human bronchial epithelial cells. | 2010 Aug |
1 |
| 28 |
18951928 | Intracellular zinc increase inhibits p53(-/-) pancreatic adenocarcinoma cell growth by ROS/AIF-mediated apoptosis. | 2009 Feb |
3 |
| 29 |
19681600 | Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast. | 2009 Sep 29 |
1 |
| 30 |
19805293 | CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53. | 2009 Sep 22 |
1 |
| 31 |
17297920 | Zn(2+)-dependent misfolding of the p53 DNA binding domain. | 2007 Mar 13 |
1 |
| 32 |
17848574 | MDM2 chaperones the p53 tumor suppressor. | 2007 Nov 9 |
1 |
| 33 |
18415980 | Phylogenetic analysis of the p53 and p63/p73 gene families. | 2007 |
1 |
| 34 |
16768444 | Effect of Zn2+ on DNA recognition and stability of the p53 DNA-binding domain. | 2006 Jun 20 |
3 |
| 35 |
15163458 | Transition metal-induced apoptosis in lymphocytes via hydroxyl radical generation, mitochondria dysfunction, and caspase-3 activation: an in vitro model for neurodegeneration. | 2004 May-Jun |
1 |
| 36 |
15242600 | Structural differences in the DNA binding domains of human p53 and its C. elegans ortholog Cep-1. | 2004 Jul |
1 |
| 37 |
12600206 | Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain. | 2003 Mar 4 |
2 |
| 38 |
12686631 | Ehp53, an Entamoeba histolytica protein, ancestor of the mammalian tumour suppressor p53. | 2003 Apr |
1 |
| 39 |
12792793 | TP53 mutations in primary breast carcinomas from white and African-Brazilian patients. | 2003 Jul |
1 |
| 40 |
12095159 | Zinc inhibits the nuclear translocation of the tumor suppressor protein p53 and protects cultured human neurons from copper-induced neurotoxicity. | 2002 |
11 |
| 41 |
12107071 | DNA damage-induced [Zn(2+)](i) transients: correlation with cell cycle arrest and apoptosis in lymphoma cells. | 2002 Aug |
5 |
| 42 |
22607421 | Effects of Oxidation Agents and Metal Ions on Binding of p53 to Supercoiled DNA. | 2000 |
1 |
| 43 |
10487521 | Induction of apoptosis by the p53-273L (Arg --> Leu) mutant in HSC3 cells without transactivation of p21Waf1/Cip1/Sdi1 and bax. | 1999 Sep |
3 |
| 44 |
10604188 | Metal ions as regulators of the conformation and function of the tumour suppressor protein p53: implications for carcinogenesis. | 1999 Aug |
2 |
| 45 |
9485322 | The Ca(2+)-dependent interaction of S100B(beta beta) with a peptide derived from p53. | 1998 Feb 17 |
1 |
| 46 |
9405613 | Thermodynamic stability of wild-type and mutant p53 core domain. | 1997 Dec 23 |
1 |
| 47 |
8552392 | A cellular protein activates the sequence-specific DNA-binding of p53 by interacting with the central conserved region. | 1996 Jan 4 |
2 |
| 48 |
7811703 | Divalent metal ions induce conformational change in pure, human wild-type p53 tumor suppressor protein. | 1994 Dec 14 |
2 |
| 49 |
8055938 | Characterization of baculovirus recombinant wild-type p53. Dimerization of p53 is required for high-affinity DNA binding and cysteine oxidation inhibits p53 DNA binding. | 1994 Jul 15 |
1 |
| 50 |
8168507 | Biochemical characterisation of purified human wild-type p53 overexpressed in insect cells. | 1994 Apr 1 |
1 |