Title : Synthetic metallochaperone ZMC1 rescues mutant p53 conformation by transporting zinc into cells as an ionophore.

Pub. Date : 2015 May

PMID : 25710967






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 p53 is a Zn(2+)-dependent tumor suppressor inactivated in >50% of human cancers. Zinc tumor protein p53 Homo sapiens
2 These [Zn(2+)]free levels are predicted to result in ~90% saturation of p53-R175H, thus accounting for its observed reactivation. Zinc tumor protein p53 Homo sapiens