Pub. Date : 2013 Jul
PMID : 23401182
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A number of previous studies have shown that zinc (Zn) modulates mitogenic activity via several signalling pathways, such as AKT, mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF -kappaB), AP-1 and p53. | Zinc | tumor protein p53 | Homo sapiens |
| 2 | Intracellular free Zn modulates p53 activity and stability, and excess Zn alters the p53 protein structure and down-regulates p53"s binding to DNA. | Zinc | tumor protein p53 | Homo sapiens |
| 3 | Intracellular free Zn modulates p53 activity and stability, and excess Zn alters the p53 protein structure and down-regulates p53"s binding to DNA. | Zinc | tumor protein p53 | Homo sapiens |
| 4 | Cu can also displace Zn from its normal binding site on p53, resulting in abnormal protein folding and disruption of p53 function. | Zinc | tumor protein p53 | Homo sapiens |
| 5 | Cu can also displace Zn from its normal binding site on p53, resulting in abnormal protein folding and disruption of p53 function. | Zinc | tumor protein p53 | Homo sapiens |