Pub. Date : 2018 Dec 3
PMID : 30230059
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The common p53 mutation Y220C causes local protein unfolding, aggregation, and can result in a loss of Zn in the DNA-binding domain. | Zinc | tumor protein p53 | Homo sapiens |
| 2 | Their Zn-binding affinity was characterized using spectroscopic methods and demonstrate the ability of compounds L4 and L5 to increase intracellular levels of Zn2+ in a p53-Y220C-mutant cell line. | Zinc | tumor protein p53 | Homo sapiens |