Title : A role for bioinorganic chemistry in the reactivation of mutant p53 in cancer.

Pub. Date : 2022 Apr 30

PMID : 35488931






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In this review, we will discuss the role of Zn in the proper function of the p53 protein in cancer. Zinc tumor protein p53 Homo sapiens
2 This includes understanding the relative populations of the Zn-bound and Zn-free p53 in wild-type and mutant forms, and the development of metallochaperones to re-populate the Zn binding site to restore mutant p53 activity. Zinc tumor protein p53 Homo sapiens
3 This includes understanding the relative populations of the Zn-bound and Zn-free p53 in wild-type and mutant forms, and the development of metallochaperones to re-populate the Zn binding site to restore mutant p53 activity. Zinc tumor protein p53 Homo sapiens