Tamoxifen

tumor protein p53 ; Homo sapiens







70 Article(s)
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1 34821461 Low concentrations of 17β-estradiol exacerbate tamoxifen resistance in breast cancer treatment through membrane estrogen receptor-mediated signaling pathways. 2022 Mar 1
2 34073371 TNFα Enhances Tamoxifen Sensitivity through Dissociation of ERα-p53-NCOR1 Complexes in ERα-Positive Breast Cancer. 2021 May 26 1
3 34681897 Suppression of Estrogen Receptor Alpha Inhibits Cell Proliferation, Differentiation and Enhances the Chemosensitivity of P53-Positive U2OS Osteosarcoma Cell. 2021 Oct 18 2
4 34779146 TP53 mutations are associated with primary endocrine resistance in luminal early breast cancer. 2021 Dec 1
5 32722075 Tamoxifen and the PI3K Inhibitor: LY294002 Synergistically Induce Apoptosis and Cell Cycle Arrest in Breast Cancer MCF-7 Cells. 2020 Jul 24 1
6 32987137 Elevated GCN5 expression confers tamoxifen resistance by upregulating AIB1 expression in ER-positive breast cancer. 2020 Dec 28 1
7 33177647 Coffee decoction enhances tamoxifen proapoptotic activity on MCF-7 cells. 2020 Nov 11 3
8 30535478 TP53 upregulates α‑smooth muscle actin expression in tamoxifen‑resistant breast cancer cells. 2019 Feb 1
9 30990221 TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer. 2019 Nov 1 2
10 29464864 Inferences of individual drug responses across diverse cancer types using a novel competing endogenous RNA network. 2018 Sep 1
11 29590203 Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells. 2018 1
12 30050469 Tamoxifen-Induced Apoptosis of MCF-7 Cells via GPR30/PI3K/MAPKs Interactions: Verification by ODE Modeling and RNA Sequencing. 2018 2
13 30285883 Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment. 2018 Oct 1 1
14 30504836 Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization. 2018 Nov 30 1
15 27888811 The role of p53 in cancer drug resistance and targeted chemotherapy. 2017 Jan 31 1
16 26909605 Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. 2016 Mar 29 1
17 25503558 Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway. 2015 Feb 1 1
18 25595558 Sp1 regulates Raf/MEK/ERK-induced p21(CIP1) transcription in TP53-mutated cancer cells. 2015 Mar 1
19 26365581 Activity of the antiestrogenic cajanin stilbene acid towards breast cancer. 2015 Nov 1
20 24361399 Premature senescence in human breast cancer and colon cancer cells by tamoxifen-mediated reactive oxygen species generation. 2014 Mar 3 5
21 24853176 MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases. 2014 Jun 10 1
22 23077249 Estrogen receptor prevents p53-dependent apoptosis in breast cancer. 2012 Oct 30 1
23 20549698 p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines. 2011 Apr 15 1
24 21191649 P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis. 2011 Nov 2
25 21547354 Effects of tamoxifen on the endometrium and its mechanism of carcinogenicity. 2011 Jun 1
26 22041887 Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells. 2011 Nov 15 1
27 30780881 Predicting response: identifying molecular determinants of endocrine response and resistance in breast cancer. 2011 Sep 1
28 19806450 Overexpression of p53 is correlated with poor outcome in premenopausal women with breast cancer treated with tamoxifen after chemotherapy. 2010 Jun 3
29 20696891 Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation. 2010 Aug 24 2
30 21119367 Expression of p53, Ki-67, and CD31 proteins in endometrial polyps of postmenopausal women treated with tamoxifen. 2010 Dec 2
31 19351845 Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells. 2009 Apr 15 1
32 19460356 Antiproliferation and apoptosis induced by tamoxifen in human bile duct carcinoma QBC939 cells via upregulated p53 expression. 2009 Jul 24 5
33 18377724 CSE1L/CAS, a microtubule-associated protein, inhibits taxol (paclitaxel)-induced apoptosis but enhances cancer cell apoptosis induced by various chemotherapeutic drugs. 2008 Mar 31 1
34 18397472 G1 arrest and expression of cyclin-dependent kinase inhibitors in tamoxifen-treated MCF-7 human breast cancer cells. 2008 May 2
35 18425390 Alterations of the K-ras and p53 genes in Tamoxifen-associated endometrial carcinoma. 2008 May 5
36 18497060 IRF-1 promotes apoptosis in p53-damaged basal-type human mammary epithelial cells: a model for early basal-type mammary carcinogenesis. 2008 4
37 20020938 CAS Enhances Chemotherapeutic Drug-Induced p53 Accumulation and Apoptosis: Use of CAS for High-Sensitivity Anticancer Drug Screening. 2008 Jan 1
38 17235397 Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. 2007 Feb 1
39 17307334 Tamoxifen-induced activation of p21Waf1/Cip1 gene transcription is mediated by Early Growth Response-1 protein through the JNK and p38 MAP kinase/Elk-1 cascades in MDA-MB-361 breast carcinoma cells. 2007 Jun 1
40 17663174 [Response to tamoxifen in estrogen receptor-positive cell line MCF-7 is independent of p53 expression]. 2007 2
41 17786323 Predictive implications of nucleoside metabolizing enzymes in premenopausal women with node-positive primary breast cancer who were randomly assigned to receive tamoxifen alone or tamoxifen plus tegafur-uracil as adjuvant therapy. 2007 Oct 1
42 16609366 p53 polymorphic variants at codon 72 and the outcome of therapy in randomized breast cancer patients. 2006 May 1
43 18603889 Evaluation of endometrial changes and p53 expression in tamoxifen treated women: comparison of various methods. 2006 Apr-Jun 1
44 15832264 Differences in oestrogen and progesterone receptors, HER-2, p53 expression and proliferation in ductal breast cancers in relation to histopathological grade. 2005 Feb 1
45 15938631 Investigating DNA adduct-targeted mutagenicity of tamoxifen: preferential formation of tamoxifen-DNA adducts in the human p53 gene in SV40 immortalized hepatocytes but not endometrial carcinoma cells. 2005 Jun 14 2
46 12684392 Combined vascular endothelial growth factor and TP53 status predicts poor response to tamoxifen therapy in estrogen receptor-positive advanced breast cancer. 2003 Apr 4
47 14633737 Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens. 2003 Nov 15 1
48 12088100 Changes in apoptosis, mitosis, Her-2, p53 and Bcl2 expression in breast carcinomas after short-term tamoxifen treatment. 2002 2
49 12376463 Tamoxifen inhibits the growth of head and neck cancer cells and sensitizes these cells to cisplatin induced-apoptosis: role of TGF-beta1. 2002 Oct 1
50 12530022 PTEN expression in tamoxifen-associated endometrial cancers. 2002 Sep-Oct 1