Title : Suppression of Estrogen Receptor Alpha Inhibits Cell Proliferation, Differentiation and Enhances the Chemosensitivity of P53-Positive U2OS Osteosarcoma Cell.

Pub. Date : 2021 Oct 18

PMID : 34681897






2 Functional Relationships(s)
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Protein Name
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1 Cotreatment with tamoxifen, an estrogen receptor inhibitor, increased the sensitivity to doxorubicin, which decreased the colony formation of P53(+) U2OS cells. Tamoxifen tumor protein p53 Homo sapiens
2 Cell cycle arrest in the S phase was observed in P53(+) U2OS cells cotreated with low doses of doxorubicin and tamoxifen, while increased levels of apoptosis factors indicated cell death. Tamoxifen tumor protein p53 Homo sapiens