Pub. Date : 2018
PMID : 30050469
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Of the 2,713 genes that were significantly upregulated following a 48 h incubation with 250 muM tamoxifen, most were categorized as either growth-related or pro-apoptotic intermediates that fit into the Tp53 and/or MAPK signaling pathways. | Tamoxifen | tumor protein p53 | Homo sapiens |
| 2 | Collectively, our results display that the effects of tamoxifen on the breast cancer MCF-7 cell line are mediated by the activation of important signaling pathways including Tp53 and MAPKs to induce apoptosis. | Tamoxifen | tumor protein p53 | Homo sapiens |