Pub. Date : 2003 Apr
PMID : 12684392
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Combined vascular endothelial growth factor and TP53 status predicts poor response to tamoxifen therapy in estrogen receptor-positive advanced breast cancer. | Tamoxifen | tumor protein p53 | Homo sapiens |
| 2 | RESULTS: In univariate analysis, both TP53 gene mutation (28% of the tumors) and a VEGF level above the median value were significantly associated with a short progression-free survival, post-relapse overall survival, and a poor rate of response to tamoxifen. | Tamoxifen | tumor protein p53 | Homo sapiens |
| 3 | In Cox multivariate regression analysis including the traditional predictive factors, the addition of TP53 gene mutation and VEGF status, alone or in combination, significantly predicted a poor efficacy of tamoxifen treatment. | Tamoxifen | tumor protein p53 | Homo sapiens |
| 4 | CONCLUSIONS: Combined TP53 gene mutation status and high VEGF levels of ER-positive primary breast tumors independently predict a poor course of the disease of patients with advanced breast cancer treated with tamoxifen. | Tamoxifen | tumor protein p53 | Homo sapiens |