Title : Estrogen receptor alpha (ERĪ±/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer.

Pub. Date : 2016 Mar 29

PMID : 26909605






1 Functional Relationships(s)
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1 Furthermore, in cell culture models, ERalpha positively regulates MDM4 and MDM2 expression via p53-independent mechanisms, and these effects can be blocked by the clinically-relevant endocrine therapies fulvestrant and tamoxifen. Tamoxifen tumor protein p53 Homo sapiens