Title : TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer.

Pub. Date : 2019 Nov 1

PMID : 30990221






2 Functional Relationships(s)
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Protein Name
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1 Tamoxifen increased ESR2-mutant TP53 interaction leading to reactivation of TP73 and apoptosis. Tamoxifen tumor protein p53 Homo sapiens
2 Our study suggests that ESR2-mutant TP53 combination prognosticates survival in TNBC revealing a novel strategy to stratify TNBC for therapeutic intervention potentially by repurposing tamoxifen. Tamoxifen tumor protein p53 Homo sapiens