Guanosine Triphosphate

HRas proto-oncogene, GTPase ; Homo sapiens







190 Article(s)
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Pub. Year
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1 35202574 Regulation of GTPase function by autophosphorylation. 2022 Mar 3 1
2 35324017 Conformations and binding pockets of HRas and its guanine nucleotide exchange factors complexes in the guanosine triphosphate exchange process. 2022 May 15 1
3 35459782 Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma. 2022 May 1
4 35462078 Millisecond molecular dynamics simulations of KRas-dimer formation and interfaces. 2022 Apr 23 1
5 30367521 In-silico identification of small molecules targeting H-Ras and in-vitro cytotoxicity with caspase-mediated apoptosis in carcinoma cells. 2019 Apr 1
6 30991803 Hybrid QM/MM vs Pure MM Molecular Dynamics for Evaluating Water Distribution within p21N-ras and the Resulting GTP Electronic Density. 2019 May 9 1
7 29235861 KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation. 2018 Jan 23 1
8 29719614 The microdomain-organizing protein MPP1 is required for insulin-stimulated activation of H-Ras. 2018 Apr 6 1
9 30141910 Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring. 2018 Sep 11 2
10 30224050 Water Distribution within Wild-Type NRas Protein and Q61 Mutants during Unrestrained QM/MM Dynamics. 2018 Oct 16 1
11 30339365 Quantitative Measurement of Intrinsic GTP Hydrolysis for Carcinogenic Glutamine 61 Mutants in H-Ras. 2018 Nov 6 1
12 27820802 Inhibition of RAS function through targeting an allosteric regulatory site. 2017 Jan 1
13 27865780 RasIns: Genetically Encoded Intrabodies of Activated Ras Proteins. 2017 Feb 17 2
14 28837923 Structural transition of solvated H-Ras/GTP revealed by molecular dynamics simulation and local network entropy. 2017 Oct 2
15 29750207 Mechanistic Insights into the Differential Catalysis by RheB and Its Mutants: Y35A and Y35A-D65A. 2017 Oct 31 1
16 26888048 The rare Costello variant HRAS c.173C>T (p.T58I) with severe neonatal hypertrophic cardiomyopathy. 2016 Jun 2
17 27057007 Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers. 2016 Jun 15 1
18 27087647 Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering. 2016 Apr 18 3
19 27412770 Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution. 2016 Jul 14 2
20 28002430 A Novel HRAS Mutation Independently Contributes to Left Ventricular Hypertrophy in a Family with a Known MYH7 Mutation. 2016 1
21 25707436 GTP-specific fab fragment-based GTPase activity assay. 2015 Mar 17 1
22 25776558 H-ras distribution and signaling in plasma membrane microdomains are regulated by acylation and deacylation events. 2015 Jun 1 2
23 25846136 Differential dynamics of RAS isoforms in GDP- and GTP-bound states. 2015 Jun 1
24 25902334 Reduced HRAS G12V-Driven Tumorigenesis of Cell Lines Expressing KRAS C118S. 2015 1
25 25935485 The structure and conformational switching of Rap1B. 2015 Jun 19 1
26 29147425 Polymorphism T81C in H-RAS Oncogene Is Associated With Disease Progression in Imatinib (TKI) Treated Chronic Myeloid Leukemia Patients. 2015 Apr 1
27 24884338 Phospholipase A/Acyltransferase enzyme activity of H-rev107 inhibits the H-RAS signaling pathway. 2014 May 1 2
28 25272152 Mechanism of the exchange reaction in HRAS from multiscale modeling. 2014 1
29 23246410 Rare codons regulate KRas oncogenesis. 2013 Jan 7 1
30 23630290 In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. 2013 May 14 3
31 23967305 Structural basis for the interaction of the adaptor protein grb14 with activated ras. 2013 1
32 24224811 Kinetic mechanisms of mutation-dependent Harvey Ras activation and their relevance for the development of Costello syndrome. 2013 Nov 26 5
33 24247240 Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination. 2013 Dec 27 1
34 24309939 Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway. 2013 Dec 5 2
35 21768877 Relationship between expression of ras p21 oncoprotein and mutation status of the K-ras gene in sporadic colorectal cancer patients in Tunisia. 2012 Mar 1
36 22231449 CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. 2012 Oct 25 1
37 22845804 Shift in the equilibrium between on and off states of the allosteric switch in Ras-GppNHp affected by small molecules and bulk solvent composition. 2012 Aug 7 1
38 21945529 Analysis of binding site hot spots on the surface of Ras GTPase. 2011 Nov 4 1
39 19995790 Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation. 2010 Mar 1 3
40 20018863 Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics. 2010 Feb 19 1
41 20080631 Ras membrane orientation and nanodomain localization generate isoform diversity. 2010 Jan 19 1
42 20700538 H-Ras nanocluster stability regulates the magnitude of MAPK signal output. 2010 Aug 5 9
43 20718707 Biomarkers downstream of RAS: a search for robust transcriptional targets. 2010 Dec 1
44 20858867 Regulation of Ras localization by acylation enables a mode of intracellular signal propagation. 2010 Sep 21 1
45 19035362 Oncogenic HRAS mutations cause prolonged PI3K signaling in response to epidermal growth factor in fibroblasts of patients with Costello syndrome. 2009 Mar 2
46 17979197 Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation. 2008 Feb 2
47 18291096 Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics. 2008 May 2 1
48 18344980 Tumour maintenance is mediated by eNOS. 2008 Apr 3 1
49 18413234 Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras. 2008 Jun 1
50 18547521 Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins. 2008 Jun 1