| 1 |
35202574 | Regulation of GTPase function by autophosphorylation. | 2022 Mar 3 |
1 |
| 2 |
35324017 | Conformations and binding pockets of HRas and its guanine nucleotide exchange factors complexes in the guanosine triphosphate exchange process. | 2022 May 15 |
1 |
| 3 |
35459782 | Targeting farnesylation as a novel therapeutic approach in HRAS-mutant rhabdomyosarcoma. | 2022 May |
1 |
| 4 |
35462078 | Millisecond molecular dynamics simulations of KRas-dimer formation and interfaces. | 2022 Apr 23 |
1 |
| 5 |
30367521 | In-silico identification of small molecules targeting H-Ras and in-vitro cytotoxicity with caspase-mediated apoptosis in carcinoma cells. | 2019 Apr |
1 |
| 6 |
30991803 | Hybrid QM/MM vs Pure MM Molecular Dynamics for Evaluating Water Distribution within p21N-ras and the Resulting GTP Electronic Density. | 2019 May 9 |
1 |
| 7 |
29235861 | KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation. | 2018 Jan 23 |
1 |
| 8 |
29719614 | The microdomain-organizing protein MPP1 is required for insulin-stimulated activation of H-Ras. | 2018 Apr 6 |
1 |
| 9 |
30141910 | Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring. | 2018 Sep 11 |
2 |
| 10 |
30224050 | Water Distribution within Wild-Type NRas Protein and Q61 Mutants during Unrestrained QM/MM Dynamics. | 2018 Oct 16 |
1 |
| 11 |
30339365 | Quantitative Measurement of Intrinsic GTP Hydrolysis for Carcinogenic Glutamine 61 Mutants in H-Ras. | 2018 Nov 6 |
1 |
| 12 |
27820802 | Inhibition of RAS function through targeting an allosteric regulatory site. | 2017 Jan |
1 |
| 13 |
27865780 | RasIns: Genetically Encoded Intrabodies of Activated Ras Proteins. | 2017 Feb 17 |
2 |
| 14 |
28837923 | Structural transition of solvated H-Ras/GTP revealed by molecular dynamics simulation and local network entropy. | 2017 Oct |
2 |
| 15 |
29750207 | Mechanistic Insights into the Differential Catalysis by RheB and Its Mutants: Y35A and Y35A-D65A. | 2017 Oct 31 |
1 |
| 16 |
26888048 | The rare Costello variant HRAS c.173C>T (p.T58I) with severe neonatal hypertrophic cardiomyopathy. | 2016 Jun |
2 |
| 17 |
27057007 | Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers. | 2016 Jun 15 |
1 |
| 18 |
27087647 | Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering. | 2016 Apr 18 |
3 |
| 19 |
27412770 | Dynamic studies of H-Ras•GTPγS interactions with nucleotide exchange factor Sos reveal a transient ternary complex formation in solution. | 2016 Jul 14 |
2 |
| 20 |
28002430 | A Novel HRAS Mutation Independently Contributes to Left Ventricular Hypertrophy in a Family with a Known MYH7 Mutation. | 2016 |
1 |
| 21 |
25707436 | GTP-specific fab fragment-based GTPase activity assay. | 2015 Mar 17 |
1 |
| 22 |
25776558 | H-ras distribution and signaling in plasma membrane microdomains are regulated by acylation and deacylation events. | 2015 Jun 1 |
2 |
| 23 |
25846136 | Differential dynamics of RAS isoforms in GDP- and GTP-bound states. | 2015 Jun |
1 |
| 24 |
25902334 | Reduced HRAS G12V-Driven Tumorigenesis of Cell Lines Expressing KRAS C118S. | 2015 |
1 |
| 25 |
25935485 | The structure and conformational switching of Rap1B. | 2015 Jun 19 |
1 |
| 26 |
29147425 | Polymorphism T81C in H-RAS Oncogene Is Associated With Disease Progression in Imatinib (TKI) Treated Chronic Myeloid Leukemia Patients. | 2015 Apr |
1 |
| 27 |
24884338 | Phospholipase A/Acyltransferase enzyme activity of H-rev107 inhibits the H-RAS signaling pathway. | 2014 May 1 |
2 |
| 28 |
25272152 | Mechanism of the exchange reaction in HRAS from multiscale modeling. | 2014 |
1 |
| 29 |
23246410 | Rare codons regulate KRas oncogenesis. | 2013 Jan 7 |
1 |
| 30 |
23630290 | In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. | 2013 May 14 |
3 |
| 31 |
23967305 | Structural basis for the interaction of the adaptor protein grb14 with activated ras. | 2013 |
1 |
| 32 |
24224811 | Kinetic mechanisms of mutation-dependent Harvey Ras activation and their relevance for the development of Costello syndrome. | 2013 Nov 26 |
5 |
| 33 |
24247240 | Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination. | 2013 Dec 27 |
1 |
| 34 |
24309939 | Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway. | 2013 Dec 5 |
2 |
| 35 |
21768877 | Relationship between expression of ras p21 oncoprotein and mutation status of the K-ras gene in sporadic colorectal cancer patients in Tunisia. | 2012 Mar |
1 |
| 36 |
22231449 | CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. | 2012 Oct 25 |
1 |
| 37 |
22845804 | Shift in the equilibrium between on and off states of the allosteric switch in Ras-GppNHp affected by small molecules and bulk solvent composition. | 2012 Aug 7 |
1 |
| 38 |
21945529 | Analysis of binding site hot spots on the surface of Ras GTPase. | 2011 Nov 4 |
1 |
| 39 |
19995790 | Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation. | 2010 Mar 1 |
3 |
| 40 |
20018863 | Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics. | 2010 Feb 19 |
1 |
| 41 |
20080631 | Ras membrane orientation and nanodomain localization generate isoform diversity. | 2010 Jan 19 |
1 |
| 42 |
20700538 | H-Ras nanocluster stability regulates the magnitude of MAPK signal output. | 2010 Aug 5 |
9 |
| 43 |
20718707 | Biomarkers downstream of RAS: a search for robust transcriptional targets. | 2010 Dec |
1 |
| 44 |
20858867 | Regulation of Ras localization by acylation enables a mode of intracellular signal propagation. | 2010 Sep 21 |
1 |
| 45 |
19035362 | Oncogenic HRAS mutations cause prolonged PI3K signaling in response to epidermal growth factor in fibroblasts of patients with Costello syndrome. | 2009 Mar |
2 |
| 46 |
17979197 | Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation. | 2008 Feb |
2 |
| 47 |
18291096 | Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics. | 2008 May 2 |
1 |
| 48 |
18344980 | Tumour maintenance is mediated by eNOS. | 2008 Apr 3 |
1 |
| 49 |
18413234 | Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras. | 2008 Jun |
1 |
| 50 |
18547521 | Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins. | 2008 Jun |
1 |