Title : Differential dynamics of RAS isoforms in GDP- and GTP-bound states.

Pub. Date : 2015 Jun

PMID : 25846136






1 Functional Relationships(s)
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1 In this study, we provide a comprehensive comparison of the dynamics of all the three RAS isoforms (HRAS, KRAS, and NRAS) using extensive molecular dynamics simulations in both the GDP- (total of 3.06 mus) and GTP-bound (total of 2.4 mus) states. Guanosine Triphosphate HRas proto-oncogene, GTPase Homo sapiens