| 1 |
32841585 | Pharmacogenomics biomarkers for personalized methadone maintenance treatment: The mechanism and its potential use. | 2021 Apr 1 |
1 |
| 2 |
33682628 | OPRM1 and CYP3A4 association with methadone dose in Iranian patients undergoing methadone maintenance therapy. | 2021 Jul-Sep |
2 |
| 3 |
34435753 | Pharmacokinetic modeling of R and S-Methadone and their metabolites to study the effects of various covariates in post-operative children. | 2021 Oct |
1 |
| 4 |
32302325 | Toward precision prescribing for methadone: Determinants of methadone deposition. | 2020 |
1 |
| 5 |
32444381 | Clinically Significant Drug-Drug Interaction Between Methadone and Cannabidiol. | 2020 Jun |
1 |
| 6 |
32870067 | Population Pharmacokinetics of Methadone after Oral Administration in Japanese Patients with Cancer-Related Pain. | 2020 Dec |
1 |
| 7 |
33410778 | ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients. | 2020 Dec 31 |
1 |
| 8 |
30973652 | Drug-Drug Interaction Studies of Methadone and Antiviral Drugs: Lessons Learned. | 2019 Aug |
2 |
| 9 |
30205091 | Methadone Metabolism and Drug-Drug Interactions: In Vitro and In Vivo Literature Review. | 2018 Dec |
2 |
| 10 |
28263461 | Current Concepts in Methadone Metabolism and Transport. | 2017 Mar |
2 |
| 11 |
29457079 | A case of a warfarinized renal cancer patient monitored for prothrombin time-international normalized ratio during methadone introduction. | 2017 |
4 |
| 12 |
27286724 | Population Genetic-Based Pharmacokinetic Modeling of Methadone and its Relationship with the QTc Interval in Opioid-Dependent Patients. | 2016 Dec |
1 |
| 13 |
25556837 | Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity. | 2015 Jun |
2 |
| 14 |
25801005 | Influence of HIV antiretrovirals on methadone N-demethylation and transport. | 2015 May 15 |
1 |
| 15 |
24500275 | Urinary diazepam metabolite distribution in a chronic pain population. | 2014 Apr |
1 |
| 16 |
25217544 | Fatal methadone toxicity: potential role of CYP3A4 genetic polymorphism. | 2014 Oct |
3 |
| 17 |
21790905 | CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction. | 2013 Jul |
1 |
| 18 |
23361846 | Role of cytochrome P4502B6 in methadone metabolism and clearance. | 2013 Mar |
2 |
| 19 |
23733841 | Mechanism of autoinduction of methadone N-demethylation in human hepatocytes. | 2013 Jul |
2 |
| 20 |
23879227 | Potential P-glycoprotein pharmacokinetic interaction of telaprevir with morphine or methadone. | 2013 Aug |
1 |
| 21 |
22148986 | Is maternal opioid use hazardous to breast-fed infants? | 2012 Jan |
1 |
| 22 |
22273859 | Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A). | 2012 Feb |
2 |
| 23 |
22369095 | Inhibition of CYP2D6-mediated tramadol O-demethylation in methadone but not buprenorphine maintenance patients. | 2012 Nov |
1 |
| 24 |
22511698 | Evaluating the relationship of methadone concentrations and EDDP formation in chronic pain patients. | 2012 May |
1 |
| 25 |
22682979 | Effect of lersivirine co-administration on pharmacokinetics of methadone in healthy volunteers. | 2012 Nov 1 |
1 |
| 26 |
22685215 | Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme. | 2012 Sep |
1 |
| 27 |
22926601 | Pharmacokinetic-pharmacodynamic modeling of mood and withdrawal symptoms in relation to plasma concentrations of methadone in patients undergoing methadone maintenance treatment. | 2012 Oct |
2 |
| 28 |
21666091 | Methadone toxicity due to smoking cessation--a case report on the drug-drug interaction involving cytochrome P450 isoenzyme 1A2. | 2011 Jun |
1 |
| 29 |
21902501 | Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients. | 2011 Oct |
4 |
| 30 |
22035341 | Methadone: a review of drug-drug and pathophysiological interactions. | 2011 Jul-Aug |
1 |
| 31 |
19133059 | Contribution of the activities of CYP3A, CYP2D6, CYP1A2 and other potential covariates to the disposition of methadone in patients undergoing methadone maintenance treatment. | 2009 Jan |
5 |
| 32 |
19232844 | Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity. | 2009 May 1 |
1 |
| 33 |
19801957 | The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test. | 2009 Nov |
1 |
| 34 |
18292673 | Role of CYP2B6 in stereoselective human methadone metabolism. | 2008 Mar |
4 |
| 35 |
18422375 | Interindividual variability of methadone response: impact of genetic polymorphism. | 2008 |
1 |
| 36 |
19238656 | Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities. | 2008 Oct |
1 |
| 37 |
19356104 | Increase of R-/S-methadone enantiomer concentration ratio in serum of patients treated with either nevirapine or efavirenz. | 2008 Dec |
1 |
| 38 |
17259447 | Enantiomeric metabolic interactions and stereoselective human methadone metabolism. | 2007 Apr |
2 |
| 39 |
17598095 | An in vitro approach to potential methadone metabolic-inhibition interactions. | 2007 Sep |
1 |
| 40 |
16595712 | Expression, purification, and characterization of mouse CYP2d22. | 2006 Jul |
1 |
| 41 |
17178267 | ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment. | 2006 Dec |
2 |
| 42 |
14628297 | Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19. | 2004 Jan |
4 |
| 43 |
14712470 | Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates. | 2004 Feb |
3 |
| 44 |
15371986 | Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone. | 2004 Sep |
5 |
| 45 |
15501692 | Methadone--metabolism, pharmacokinetics and interactions. | 2004 Dec |
3 |
| 46 |
12609702 | Cytochrome P4503A4 metabolic activity, methadone blood concentrations, and methadone doses. | 2003 Mar 1 |
5 |
| 47 |
12756206 | Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro. | 2003 Jun |
5 |
| 48 |
12791438 | High dose methadone and ventricular arrhythmias: a report of three cases. | 2003 Jun |
1 |
| 49 |
12900870 | Capillary electrophoresis to assess drug metabolism induced in vitro using single CYP450 enzymes (Supersomes): application to the chiral metabolism of mephenytoin and methadone. | 2003 Aug |
2 |
| 50 |
14587370 | [Torsade de pointes: a severe and unknown adverse effect in a patient taking methadone]. | 2003 Oct 8 |
1 |