Pub. Date : 2004 Dec
PMID : 15501692
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methadone is mostly metabolised in the liver; the main step consists in the N-demethylation by CYP3A4 to EDDP (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine), an inactive metabolite. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The activity of CYP3A4 varies considerably among individuals, and such variability is the responsible for the large differences in methadone bioavailability. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | In particular, antiretrovirals, which are CYP3A4 inducers, can decrease the levels of methadone, so causing withdrawal symptoms. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |