Pub. Date : 2011 Oct
PMID : 21902501
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The isozyme CYP3A4 of the CYP system is one of the metabolic enzymes, as well as CYP2B6, responsible for the metabolism of methadone. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The aim of the present study is to evaluate the potential use of genetic polymorphisms in CYP3A4 as biomarkers for the prediction of methadone treatment responses. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | CONCLUSION: These results suggested that genetic variants in the CYP3A4 gene may be useful indicators for the severity of side effects and withdrawal symptoms for methadone treatment. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |