Pub. Date : 2014 Oct
PMID : 25217544
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP3A4 is one of the primary CYP450 isoforms responsible for the metabolism of methadone to EDDP in humans. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The purpose of this study was to evaluate the role of CYP3A4 genetic polymorphisms in accidental methadone fatalities. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Our findings indicate that there may be two or more SNPs on the CYP3A4 gene that cause or contribute to the methadone poor metabolizer phenotype. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |