Title : Pharmacokinetic-pharmacodynamic modeling of mood and withdrawal symptoms in relation to plasma concentrations of methadone in patients undergoing methadone maintenance treatment.

Pub. Date : 2012 Oct

PMID : 22926601






2 Functional Relationships(s)
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1 Multiple regression analysis revealed that 33% of the overall variation in unbound (R)-methadone EC50 was explained by 3 variables, namely CYP3A activity (9%), age (16%), and sex (8%). Methadone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Finally, it was established that CYP3A activity, years of dependent use, sex, and age are major determinants of methadone EC50 with respect to TMDS. Methadone cytochrome P450 family 3 subfamily A member 4 Homo sapiens