Pub. Date : 2003 Jun
PMID : 12756206
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Based on studies with isoform-selective chemical inhibitors and expressed enzymes, CYP3A4 was the predominant enzyme involved in the metabolism of (R)-methadone. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In recombinant CYP3A4, the metabolic clearance of (R)-methadone was about 4-fold higher than that of (S)-methadone. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | In recombinant CYP3A4, the metabolic clearance of (R)-methadone was about 4-fold higher than that of (S)-methadone. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The present in vitro findings indicated that CYP3A4, CYP2C8, and CYP2D6 are all involved in the stereoselective metabolism of methadone (R)- and (S)-enantiomers. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | These data suggest that coadministration of inhibitors of CYP3A4 and CYP2C8 may produce clinically significant drug-drug interactions with methadone. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |