Title : Influence of HIV antiretrovirals on methadone N-demethylation and transport.

Pub. Date : 2015 May 15

PMID : 25801005






1 Functional Relationships(s)
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1 Methadone is N-demethylated to 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) by CYP2B6 and CYP3A4 in vitro, but by CYP2B6 in vivo. Methadone cytochrome P450 family 3 subfamily A member 4 Homo sapiens