Title : Mechanism-based inactivation of cytochrome P450 2B6 by methadone through destruction of prosthetic heme.

Pub. Date : 2012 Sep

PMID : 22685215






1 Functional Relationships(s)
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1 Initial in vitro data suggested that CYP3A4 is the major isoform responsible for the in vivo clearance of methadone in humans. Methadone cytochrome P450 family 3 subfamily A member 4 Homo sapiens