Pub. Date : 2013 Jul
PMID : 23733841
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although methadone N-demethylation is catalyzed in vitro by cytochrome P4502B6 (CYP2B6) and CYP3A4, and clearance in vivo depends on CYP2B6, mechanism(s) of autoinduction are incompletely understood. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | CONCLUSIONS: Methadone caused concentration-dependent autoinduction of methadone N-demethylation in human hepatocytes, related to induction of CYP2B6 and CYP3A4 mRNA expression, protein expression, and catalytic activity. | Methadone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |