Pub. Date : 2016 May
PMID : 27225724
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of Genetic Polymorphism in CYP3A4 and CYP3A5 Genes on Tacrolimus Dose Among Kidney Transplant Recipients. | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | INTRODUCTION: This study aimed to evaluate the effects of single nucleotide polymorphisms CYP3A4*1B and CYP3A5*3 on tacrolimus dose requirement among kidney transplant recipients. | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | RESULTS: The median tacrolimus dose was significantly lower in the CYP3A4*1/*1 carriers (0.06 mg/kg/d; range, 0.007 mg/kg/d to 0.17 mg/kg/d) as compared to the CYP3A4*1B/*1B carriers (0.1 mg/kg/d; range, 0.03 mg/kg/d to 0.22 mg/kg/d; P = .001). | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | RESULTS: The median tacrolimus dose was significantly lower in the CYP3A4*1/*1 carriers (0.06 mg/kg/d; range, 0.007 mg/kg/d to 0.17 mg/kg/d) as compared to the CYP3A4*1B/*1B carriers (0.1 mg/kg/d; range, 0.03 mg/kg/d to 0.22 mg/kg/d; P = .001). | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Moreover, we found a correlation between genetic variations in CYP3A4 and CYP3A5 enzymes and tacrolimus blood levels among our kidney transplant recipients. | Tacrolimus | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |