Title : Long-Term Influence of CYP3A5, CYP3A4, ABCB1, and NR1I2 Polymorphisms on Tacrolimus Concentration in Chinese Renal Transplant Recipients.

Pub. Date : 2017 Nov

PMID : 28945481






3 Functional Relationships(s)
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1 RESULTS: The alleles CYP3A5*3 and CYP3A4*18B were significantly associated with dose-adjusted tacrolimus blood trough concentrations and had a strong time-genotype interaction with tacrolimus pharmacokinetics. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 RESULTS: The alleles CYP3A5*3 and CYP3A4*18B were significantly associated with dose-adjusted tacrolimus blood trough concentrations and had a strong time-genotype interaction with tacrolimus pharmacokinetics. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 Thus, genotyping of the CYP3A4 and CYP3A5 genes should be considered with respect to determining tacrolimus dose regimens during the post-transplantation period. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens