| 1 |
35064691 | Inhibition of MAT2A suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss. | 2022 Feb |
4 |
| 2 |
35159219 | S-Adenosylmethionine: From the Discovery of Its Inhibition of Tumorigenesis to Its Use as a Therapeutic Agent. | 2022 Jan 25 |
2 |
| 3 |
35182729 | Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer. | 2022 Mar |
2 |
| 4 |
35293760 | Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. | 2022 Mar 24 |
2 |
| 5 |
33450196 | MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage. | 2021 Feb 8 |
2 |
| 6 |
33656855 | Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A. | 2021 Mar 16 |
2 |
| 7 |
33756106 | mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis. | 2021 May 20 |
4 |
| 8 |
33829783 | Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. | 2021 Apr 22 |
2 |
| 9 |
34065390 | MAT2A Localization and Its Independently Prognostic Relevance in Breast Cancer Patients. | 2021 May 20 |
2 |
| 10 |
34616406 | MAT2A-Mediated S-Adenosylmethionine Level in CD4+ T Cells Regulates HIV-1 Latent Infection. | 2021 |
3 |
| 11 |
34668717 | Mechanism of Triphosphate Hydrolysis by Human MAT2A at 1.07 Å Resolution. | 2021 Nov 3 |
3 |
| 12 |
34780697 | Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B. | 2021 Nov 30 |
1 |
| 13 |
32456310 | MAT2A as Key Regulator and Therapeutic Target in MLLr Leukemogenesis. | 2020 May 24 |
4 |
| 14 |
30265288 | Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition†. | 2019 Mar 1 |
1 |
| 15 |
30591370 | Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytes. | 2019 Jan |
1 |
| 16 |
30712196 | S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells. | 2019 May |
2 |
| 17 |
31293025 | MAT2A/2B promote porcine intramuscular preadipocyte proliferation through ERK signaling pathway. | 2019 Sep |
1 |
| 18 |
31354356 | MAT2B expression correlates with poor prognosis in triple-negative breast cancer. | 2019 |
2 |
| 19 |
27678102 | Variable Methylation Potential in Preterm Placenta: Implication for Epigenetic Programming of the Offspring. | 2017 Jun |
2 |
| 20 |
28553945 | Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. | 2017 Jul |
1 |
| 21 |
28880543 | The Transition-State Structure for Human MAT2A from Isotope Effects. | 2017 Oct 4 |
2 |
| 22 |
29108270 | S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis. | 2017 Oct 3 |
1 |
| 23 |
29707653 | Methyl donor deficient diets cause distinct alterations in lipid metabolism but are poorly representative of human NAFLD. | 2017 |
1 |
| 24 |
26418898 | Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells. | 2016 Mar 22 |
2 |
| 25 |
26940012 | MAT2B promotes adipogenesis by modulating SAMe levels and activating AKT/ERK pathway during porcine intramuscular preadipocyte differentiation. | 2016 May 15 |
1 |
| 26 |
27068473 | MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis. | 2016 Apr 19 |
2 |
| 27 |
25925782 | Acetylation of MAT IIα represses tumour cell growth and is decreased in human hepatocellular cancer. | 2015 Apr 30 |
2 |
| 28 |
26416353 | Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells. | 2015 Nov 10 |
2 |
| 29 |
24636201 | Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis. | 2014 Mar 17 |
2 |
| 30 |
27508177 | New insights on the role of epigenetic alterations in hepatocellular carcinoma. | 2014 |
2 |
| 31 |
23363077 | Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. | 2013 Apr 19 |
4 |
| 32 |
23453262 | Inhibition of proteolysis in histiotrophic nutrition pathways alters DNA methylation and one-carbon metabolism in the organogenesis-stage rat conceptus. | 2013 Aug |
4 |
| 33 |
22879628 | The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease. | 2012 Nov |
3 |
| 34 |
21247894 | The X protein of hepatitis B virus inhibits apoptosis in hepatoma cells through enhancing the methionine adenosyltransferase 2A gene expression and reducing S-adenosylmethionine production. | 2011 May 13 |
2 |
| 35 |
21460102 | Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells. | 2011 Jun |
2 |
| 36 |
21994249 | New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes. | 2011 Nov |
1 |
| 37 |
20102719 | HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. | 2010 May |
3 |
| 38 |
20363925 | Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice. | 2010 May |
1 |
| 39 |
19048023 | Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells. | 2009 Mar |
2 |
| 40 |
17869084 | Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression. | 2008 Jun |
1 |
| 41 |
18487201 | Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells. | 2008 Jul 11 |
2 |
| 42 |
17317269 | Transcription of the MAT2A gene, coding for methionine adenosyltransferase, is up-regulated by E2F and Sp1 at a chromatin level during proliferation of liver cells. | 2007 |
1 |
| 43 |
17631143 | Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. | 2007 Jul |
1 |
| 44 |
16054984 | Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. | 2005 Apr |
1 |
| 45 |
12660248 | L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. | 2003 May 30 |
3 |
| 46 |
12671891 | Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. | 2003 Apr |
2 |
| 47 |
14530285 | Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1. | 2003 Dec 19 |
1 |
| 48 |
11208539 | Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. | 2001 Feb |
1 |
| 49 |
11320206 | Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. | 2001 May 8 |
1 |
| 50 |
10216131 | Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat. | 1999 May |
2 |