PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33756106-2 2021 We found that mTORC1 stimulates the synthesis of the major methyl donor, S-adenosylmethionine (SAM), through the control of methionine adenosyltransferase 2 alpha (MAT2A) expression. S-Adenosylmethionine 73-93 methionine adenosyltransferase 2A Homo sapiens 124-162 33756106-2 2021 We found that mTORC1 stimulates the synthesis of the major methyl donor, S-adenosylmethionine (SAM), through the control of methionine adenosyltransferase 2 alpha (MAT2A) expression. S-Adenosylmethionine 73-93 methionine adenosyltransferase 2A Homo sapiens 164-169 33756106-2 2021 We found that mTORC1 stimulates the synthesis of the major methyl donor, S-adenosylmethionine (SAM), through the control of methionine adenosyltransferase 2 alpha (MAT2A) expression. S-Adenosylmethionine 95-98 methionine adenosyltransferase 2A Homo sapiens 124-162 33756106-2 2021 We found that mTORC1 stimulates the synthesis of the major methyl donor, S-adenosylmethionine (SAM), through the control of methionine adenosyltransferase 2 alpha (MAT2A) expression. S-Adenosylmethionine 95-98 methionine adenosyltransferase 2A Homo sapiens 164-169 33829783-4 2021 Fragment screening followed by iterative structure-guided design enabled >10 000-fold improvement in potency of a family of allosteric MAT2A inhibitors that are substrate noncompetitive and inhibit release of the product, S-adenosyl methionine (SAM), from the enzyme"s active site. S-Adenosylmethionine 222-243 methionine adenosyltransferase 2A Homo sapiens 135-140 33829783-4 2021 Fragment screening followed by iterative structure-guided design enabled >10 000-fold improvement in potency of a family of allosteric MAT2A inhibitors that are substrate noncompetitive and inhibit release of the product, S-adenosyl methionine (SAM), from the enzyme"s active site. S-Adenosylmethionine 245-248 methionine adenosyltransferase 2A Homo sapiens 135-140 30712196-1 2019 PURPOSE: Many transformed cells and embryonic stem cells are dependent on the biosynthesis of the universal methyl-donor S-adenosylmethionine (SAM) from methionine by the enzyme MAT2A to maintain their epigenome. S-Adenosylmethionine 121-141 methionine adenosyltransferase 2A Homo sapiens 178-183 32456310-2 2020 S-adenosylmethionine (SAM) is the universal methyl donor in human cells and is synthesized by methionine adenosyltransferase 2A (MAT2A), which is deregulated in different cancer types. S-Adenosylmethionine 0-20 methionine adenosyltransferase 2A Homo sapiens 94-127 32456310-2 2020 S-adenosylmethionine (SAM) is the universal methyl donor in human cells and is synthesized by methionine adenosyltransferase 2A (MAT2A), which is deregulated in different cancer types. S-Adenosylmethionine 0-20 methionine adenosyltransferase 2A Homo sapiens 129-134 32456310-2 2020 S-adenosylmethionine (SAM) is the universal methyl donor in human cells and is synthesized by methionine adenosyltransferase 2A (MAT2A), which is deregulated in different cancer types. S-Adenosylmethionine 22-25 methionine adenosyltransferase 2A Homo sapiens 94-127 32456310-2 2020 S-adenosylmethionine (SAM) is the universal methyl donor in human cells and is synthesized by methionine adenosyltransferase 2A (MAT2A), which is deregulated in different cancer types. S-Adenosylmethionine 22-25 methionine adenosyltransferase 2A Homo sapiens 129-134 31293025-2 2019 MAT2A and MAT2B coordinately catalyzes the synthesis of the major biological methyl donor S-adenosylmethionine (SAMe). S-Adenosylmethionine 90-110 methionine adenosyltransferase 2A Homo sapiens 0-5 31354356-1 2019 Background: In conjunction with the methionine adenosyltransferase 2A (MAT2A), MAT2B protein catalyses the formation of methyl donor S-adenosylmethionine to mediate cell metabolism, including proliferation and apoptosis. S-Adenosylmethionine 133-153 methionine adenosyltransferase 2A Homo sapiens 36-69 31354356-1 2019 Background: In conjunction with the methionine adenosyltransferase 2A (MAT2A), MAT2B protein catalyses the formation of methyl donor S-adenosylmethionine to mediate cell metabolism, including proliferation and apoptosis. S-Adenosylmethionine 133-153 methionine adenosyltransferase 2A Homo sapiens 71-76 33656855-1 2021 S-Adenosyl-l-methionine (AdoMet) is synthesized by the MAT2A isozyme of methionine adenosyltransferase in most human tissues and in cancers. S-Adenosylmethionine 0-23 methionine adenosyltransferase 2A Homo sapiens 55-60 33656855-1 2021 S-Adenosyl-l-methionine (AdoMet) is synthesized by the MAT2A isozyme of methionine adenosyltransferase in most human tissues and in cancers. S-Adenosylmethionine 25-31 methionine adenosyltransferase 2A Homo sapiens 55-60 33450196-4 2021 We report the characterization of potent MAT2A inhibitors that substantially reduce levels of S-adenosylmethionine (SAM) and demonstrate antiproliferative activity in MTAP-deleted cancer cells and tumors. S-Adenosylmethionine 94-114 methionine adenosyltransferase 2A Homo sapiens 41-46 33450196-4 2021 We report the characterization of potent MAT2A inhibitors that substantially reduce levels of S-adenosylmethionine (SAM) and demonstrate antiproliferative activity in MTAP-deleted cancer cells and tumors. S-Adenosylmethionine 116-119 methionine adenosyltransferase 2A Homo sapiens 41-46 30712196-1 2019 PURPOSE: Many transformed cells and embryonic stem cells are dependent on the biosynthesis of the universal methyl-donor S-adenosylmethionine (SAM) from methionine by the enzyme MAT2A to maintain their epigenome. S-Adenosylmethionine 143-146 methionine adenosyltransferase 2A Homo sapiens 178-183 28880543-1 2017 Human methionine S-adenosyltransferase (MAT2A) catalyzes the formation of S-adenosylmethionine (SAM) from ATP and methionine. S-Adenosylmethionine 74-94 methionine adenosyltransferase 2A Homo sapiens 40-45 30591370-6 2019 FINDINGS: AKBA directly interacts with methionine adenosyltransferase 2A (MAT2A), inhibited its enzyme activity, decreased level of S-adenosylmethionine (SAM) and SAM/SAH ratio, and reprogrammed one-carbon metabolism in HaCaT cells. S-Adenosylmethionine 132-152 methionine adenosyltransferase 2A Homo sapiens 74-79 30265288-1 2019 Methionine adenosyltransferase II (MAT2A) is essential to the synthesis of S-adenosylmethionine, a major methyl donor, from L-methionine and ATP. S-Adenosylmethionine 75-95 methionine adenosyltransferase 2A Homo sapiens 35-40 28880543-1 2017 Human methionine S-adenosyltransferase (MAT2A) catalyzes the formation of S-adenosylmethionine (SAM) from ATP and methionine. S-Adenosylmethionine 96-99 methionine adenosyltransferase 2A Homo sapiens 40-45 29707653-6 2017 With respect to 1-carbon metabolism, down-regulation of Chka, Chkb, Pcty1a, Gnmt and Ahcy with concurrent upregulation of Mat2a suggests a drive to maintain S-adenosylmethionine levels. S-Adenosylmethionine 159-177 methionine adenosyltransferase 2A Homo sapiens 122-127 28553945-0 2017 Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A. S-Adenosylmethionine 12-30 methionine adenosyltransferase 2A Homo sapiens 81-86 29108270-0 2017 S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis. S-Adenosylmethionine 0-20 methionine adenosyltransferase 2A Homo sapiens 99-132 26416353-2 2015 Methionine adenosyltransferase 2A (MAT2A) encodes for MATalpha2, the catalytic subunit of the MATII isoenzyme that synthesizes S-adenosylmethionine (SAMe). S-Adenosylmethionine 127-147 methionine adenosyltransferase 2A Homo sapiens 0-33 27678102-5 2017 We postulate that alterations in the micronutrient metabolism may affect the regulation of enzymes, methionine adenosyltransferase ( MAT2A), and SAH-hydrolase ( AHCY), involved in the production of methyl donor S-adenosylmethionine (SAM), thereby influencing the methylation potential (MP) in the placenta of women delivering preterm. S-Adenosylmethionine 211-231 methionine adenosyltransferase 2A Homo sapiens 133-138 27678102-5 2017 We postulate that alterations in the micronutrient metabolism may affect the regulation of enzymes, methionine adenosyltransferase ( MAT2A), and SAH-hydrolase ( AHCY), involved in the production of methyl donor S-adenosylmethionine (SAM), thereby influencing the methylation potential (MP) in the placenta of women delivering preterm. S-Adenosylmethionine 233-236 methionine adenosyltransferase 2A Homo sapiens 133-138 26940012-2 2016 The MAT2B protein with MAT2alpha catalyzes the formation of methyl donor S- adenosylmethionine (SAMe) to mediate cell metabolism including proliferation and apoptosis. S-Adenosylmethionine 73-94 methionine adenosyltransferase 2A Homo sapiens 23-32 27068473-7 2016 MAT2A produces the PRMT5 substrate S-adenosylmethionine (SAM), and MAT2A depletion reduces growth and PRMT5 methylation activity selectively in MTAP-deleted cells. S-Adenosylmethionine 35-55 methionine adenosyltransferase 2A Homo sapiens 0-5 27068473-7 2016 MAT2A produces the PRMT5 substrate S-adenosylmethionine (SAM), and MAT2A depletion reduces growth and PRMT5 methylation activity selectively in MTAP-deleted cells. S-Adenosylmethionine 57-60 methionine adenosyltransferase 2A Homo sapiens 0-5 26418898-2 2016 Here, we found that the basal expression level of methionine adenosyltransferase 2A (MAT2A), a critical enzyme for the biosynthesis of S-adenosylmethionine, was up-regulated in TAMR-MCF-7 cells compared with control MCF-7 cells. S-Adenosylmethionine 135-155 methionine adenosyltransferase 2A Homo sapiens 50-83 26418898-2 2016 Here, we found that the basal expression level of methionine adenosyltransferase 2A (MAT2A), a critical enzyme for the biosynthesis of S-adenosylmethionine, was up-regulated in TAMR-MCF-7 cells compared with control MCF-7 cells. S-Adenosylmethionine 135-155 methionine adenosyltransferase 2A Homo sapiens 85-90 26416353-2 2015 Methionine adenosyltransferase 2A (MAT2A) encodes for MATalpha2, the catalytic subunit of the MATII isoenzyme that synthesizes S-adenosylmethionine (SAMe). S-Adenosylmethionine 127-147 methionine adenosyltransferase 2A Homo sapiens 35-40 24636201-1 2014 BACKGROUND: Methionine adenosyltransferase 2A (MAT2A) is an enzyme that catalyzes the formation of S-adenosylmethionine (SAMe) by joining methionine and ATP. S-Adenosylmethionine 99-119 methionine adenosyltransferase 2A Homo sapiens 12-45 25925782-3 2015 Methionine adenosyltransferase IIalpha (MAT IIalpha) is a key enzyme in the methionine cycle, catalysing the production of S-adenosylmethionine (SAM), a key methyl donor in cellular processes, and is associated with uncontrolled cell proliferation in cancer. S-Adenosylmethionine 123-143 methionine adenosyltransferase 2A Homo sapiens 0-51 25925782-3 2015 Methionine adenosyltransferase IIalpha (MAT IIalpha) is a key enzyme in the methionine cycle, catalysing the production of S-adenosylmethionine (SAM), a key methyl donor in cellular processes, and is associated with uncontrolled cell proliferation in cancer. S-Adenosylmethionine 145-148 methionine adenosyltransferase 2A Homo sapiens 0-51 27508177-4 2014 Alterations in the methylation of the promoter of methyl adenosyltransferase MAT1A and MAT2A genes in HCC result in decreased S-adenosylmethionine levels, global DNA hypomethylation, and deregulation of signal transduction pathways linked to methionine metabolism and methyl adenosyltransferases activity. S-Adenosylmethionine 126-146 methionine adenosyltransferase 2A Homo sapiens 87-92 27508177-5 2014 Changes in S-adenosylmethionine levels may also depend on MAT1A mRNA destabilization associated with MAT2A mRNA stabilization by specific proteins. S-Adenosylmethionine 11-31 methionine adenosyltransferase 2A Homo sapiens 101-106 24636201-1 2014 BACKGROUND: Methionine adenosyltransferase 2A (MAT2A) is an enzyme that catalyzes the formation of S-adenosylmethionine (SAMe) by joining methionine and ATP. S-Adenosylmethionine 99-119 methionine adenosyltransferase 2A Homo sapiens 47-52 23453262-2 2013 The methyl donor, S-adenosylmethionine (SAM), is biosynthesized from methionine and adenosine triphosphate by methionine adenosyltransferase 2a (Mat2a) in the one-carbon (C1) metabolism pathway. S-Adenosylmethionine 18-38 methionine adenosyltransferase 2A Homo sapiens 110-143 23453262-2 2013 The methyl donor, S-adenosylmethionine (SAM), is biosynthesized from methionine and adenosine triphosphate by methionine adenosyltransferase 2a (Mat2a) in the one-carbon (C1) metabolism pathway. S-Adenosylmethionine 18-38 methionine adenosyltransferase 2A Homo sapiens 145-150 23453262-2 2013 The methyl donor, S-adenosylmethionine (SAM), is biosynthesized from methionine and adenosine triphosphate by methionine adenosyltransferase 2a (Mat2a) in the one-carbon (C1) metabolism pathway. S-Adenosylmethionine 40-43 methionine adenosyltransferase 2A Homo sapiens 110-143 23453262-2 2013 The methyl donor, S-adenosylmethionine (SAM), is biosynthesized from methionine and adenosine triphosphate by methionine adenosyltransferase 2a (Mat2a) in the one-carbon (C1) metabolism pathway. S-Adenosylmethionine 40-43 methionine adenosyltransferase 2A Homo sapiens 145-150 23363077-1 2013 Methionine S-adenosyltransferase 2A (MAT2A) is the catalytic subunit for synthesis of S-adenosylmethionine (SAM), the principal methyl donor in many biological processes. S-Adenosylmethionine 86-106 methionine adenosyltransferase 2A Homo sapiens 0-35 23363077-1 2013 Methionine S-adenosyltransferase 2A (MAT2A) is the catalytic subunit for synthesis of S-adenosylmethionine (SAM), the principal methyl donor in many biological processes. S-Adenosylmethionine 86-106 methionine adenosyltransferase 2A Homo sapiens 37-42 23363077-1 2013 Methionine S-adenosyltransferase 2A (MAT2A) is the catalytic subunit for synthesis of S-adenosylmethionine (SAM), the principal methyl donor in many biological processes. S-Adenosylmethionine 108-111 methionine adenosyltransferase 2A Homo sapiens 0-35 23363077-1 2013 Methionine S-adenosyltransferase 2A (MAT2A) is the catalytic subunit for synthesis of S-adenosylmethionine (SAM), the principal methyl donor in many biological processes. S-Adenosylmethionine 108-111 methionine adenosyltransferase 2A Homo sapiens 37-42 22879628-0 2012 The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer"s disease. S-Adenosylmethionine 70-90 methionine adenosyltransferase 2A Homo sapiens 104-109 22879628-7 2012 MAT2A catalyzes the production of S-adenosylmethionine from methionine and ATP, which plays a pivotal role in the methylation of neurotransmitters, DNA, proteins, and lipids. S-Adenosylmethionine 34-54 methionine adenosyltransferase 2A Homo sapiens 0-5 22879628-8 2012 MAT2A-dependent significant up-regulation of S-adenosylmethionine was also detectable in the knockdown cells compared with controls. S-Adenosylmethionine 45-65 methionine adenosyltransferase 2A Homo sapiens 0-5 21994249-9 2011 Examples include two hypothesized auto-regulatory feedback mechanisms: one involving six long hairpins in the 3"-UTR of MAT2A, a key metabolic gene that produces the primary human methyl donor S-adenosylmethionine; the other involving a tRNA-like structure in the intron of the tRNA maturation gene POP1. S-Adenosylmethionine 193-213 methionine adenosyltransferase 2A Homo sapiens 120-125 18487201-4 2008 A marked suppression of S-adenosylmethionine (SAM) levels occurred with decreased methionine adenosyltransferase 2A (converts methionine to SAM) expression and increased negative regulator methionine adenosyltransferase B, suggesting reduced conversion of Hcy to SAM. S-Adenosylmethionine 24-44 methionine adenosyltransferase 2A Homo sapiens 82-115 21460102-3 2011 Methionine adenosyltransferase 2A (MAT2A) maintains the homeostasis of S-adenosylmethionine (SAM), a critical marker of genomic methylation status. S-Adenosylmethionine 71-91 methionine adenosyltransferase 2A Homo sapiens 0-33 21460102-3 2011 Methionine adenosyltransferase 2A (MAT2A) maintains the homeostasis of S-adenosylmethionine (SAM), a critical marker of genomic methylation status. S-Adenosylmethionine 71-91 methionine adenosyltransferase 2A Homo sapiens 35-40 21247894-1 2011 The X protein (HBx) of hepatitis B virus (HBV) is involved in the development of hepatocellular carcinoma (HCC), and methionine adenosyltransferase 2A (MAT2A) promotes the growth of liver cancer cells through altering S-adenosylmethionine homeostasis. S-Adenosylmethionine 220-238 methionine adenosyltransferase 2A Homo sapiens 152-157 21247894-9 2011 Thus, we proposed that HBx activates MAT2A expression through NF-kappaB and CREB signaling pathways to reduce AdoMet production, inhibit hepatoma cell apoptosis, and perhaps enhance HCC development. S-Adenosylmethionine 110-116 methionine adenosyltransferase 2A Homo sapiens 37-42 20363925-1 2010 Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the principal methyl donor, and is encoded by MAT1A and MAT2A in mammals. S-Adenosylmethionine 64-84 methionine adenosyltransferase 2A Homo sapiens 142-147 20102719-1 2010 BACKGROUND & AIMS: Hepatic de-differentiation, liver development, and malignant transformation are processes in which the levels of hepatic S-adenosylmethionine are tightly regulated by 2 genes: methionine adenosyltransferase 1A (MAT1A) and methionine adenosyltransferase 2A (MAT2A). S-Adenosylmethionine 144-164 methionine adenosyltransferase 2A Homo sapiens 245-278 20102719-1 2010 BACKGROUND & AIMS: Hepatic de-differentiation, liver development, and malignant transformation are processes in which the levels of hepatic S-adenosylmethionine are tightly regulated by 2 genes: methionine adenosyltransferase 1A (MAT1A) and methionine adenosyltransferase 2A (MAT2A). S-Adenosylmethionine 144-164 methionine adenosyltransferase 2A Homo sapiens 280-285 20102719-7 2010 S-adenosylmethionine treatment altered this homeostasis by shifting the balance of AUF1 and methyl-HuR/HuR, which was identified as an inhibitor of MAT2A messenger RNA (mRNA) stability. S-Adenosylmethionine 0-20 methionine adenosyltransferase 2A Homo sapiens 148-153 19048023-1 2009 Methionine adenosyltransferase II (MAT II) is a key enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. S-Adenosylmethionine 113-133 methionine adenosyltransferase 2A Homo sapiens 0-33 19048023-1 2009 Methionine adenosyltransferase II (MAT II) is a key enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. S-Adenosylmethionine 113-133 methionine adenosyltransferase 2A Homo sapiens 35-41 18487201-4 2008 A marked suppression of S-adenosylmethionine (SAM) levels occurred with decreased methionine adenosyltransferase 2A (converts methionine to SAM) expression and increased negative regulator methionine adenosyltransferase B, suggesting reduced conversion of Hcy to SAM. S-Adenosylmethionine 46-49 methionine adenosyltransferase 2A Homo sapiens 82-115 16054984-1 2005 Two genes (MAT1A and MAT2A) encode for the essential enzyme methionine adenosyltransferase (MAT), which catalyzes the biosynthesis of S-adenosylmethionine (SAMe), the principal methyl donor and, in the liver, a precursor of glutathione. S-Adenosylmethionine 134-154 methionine adenosyltransferase 2A Homo sapiens 21-26 17317269-11 2007 In summary, the present work shows that the molecular mechanism of MAT2A expression is different during G0-G1 or G1-S transition and this may be related to the distinct requirements of S-adenosylmethionine during liver regeneration. S-Adenosylmethionine 185-205 methionine adenosyltransferase 2A Homo sapiens 67-72 17869084-3 2008 It has been demonstrated that the formation of S-adenosylmethionine (SAMe) catalyzed by methionine adenosyltransferase (MAT) II is essential for CD4(+) T-cell activation and proliferation. S-Adenosylmethionine 47-67 methionine adenosyltransferase 2A Homo sapiens 88-127 17631143-1 2007 BACKGROUND & AIMS: Two genes (MAT1A and MAT2A) encode for methionine adenosyltransferase, an essential enzyme responsible for S-adenosylmethionine (SAMe) biosynthesis. S-Adenosylmethionine 130-150 methionine adenosyltransferase 2A Homo sapiens 44-49 12671891-1 2003 BACKGROUND & AIMS: Of the 2 genes (MAT1A, MAT2A) encoding methionine adenosyltransferase, the enzyme that synthesizes S-adenosylmethionine, MAT1A, is expressed in liver, whereas MAT2A is expressed in extrahepatic tissues. S-Adenosylmethionine 122-142 methionine adenosyltransferase 2A Homo sapiens 46-51 12660248-1 2003 In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. S-Adenosylmethionine 77-97 methionine adenosyltransferase 2A Homo sapiens 153-158 12660248-1 2003 In mammals, methionine adenosyltransferase (MAT), the enzyme responsible for S-adenosylmethionine (AdoMet) synthesis, is encoded by two genes, MAT1A and MAT2A. S-Adenosylmethionine 99-105 methionine adenosyltransferase 2A Homo sapiens 153-158 12660248-5 2003 Restoration of l-methionine rapidly down-regulates MAT2A mRNA levels; for this effect, l-methionine needs to be converted into AdoMet. S-Adenosylmethionine 127-133 methionine adenosyltransferase 2A Homo sapiens 51-56 14530285-2 2003 Two genes (MAT1A and MAT2A) encode for methionine adenosyltransferase (MAT), an essential cellular enzyme responsible for S-adenosylmethionine biosynthesis. S-Adenosylmethionine 122-142 methionine adenosyltransferase 2A Homo sapiens 21-26 12671891-1 2003 BACKGROUND & AIMS: Of the 2 genes (MAT1A, MAT2A) encoding methionine adenosyltransferase, the enzyme that synthesizes S-adenosylmethionine, MAT1A, is expressed in liver, whereas MAT2A is expressed in extrahepatic tissues. S-Adenosylmethionine 122-142 methionine adenosyltransferase 2A Homo sapiens 182-187 11208539-1 2001 Methionine adenosyltransferase (MAT), an essential enzyme that catalyzes the formation of S-adenosylmethionine (SAM), is encoded by two genes, MAT1A (liver-specific) and MAT2A (non-liver-specific). S-Adenosylmethionine 90-110 methionine adenosyltransferase 2A Homo sapiens 170-175 11320206-1 2001 Liver-specific and nonliver-specific methionine adenosyltransferases (MATs) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (AdoMet), the principal biological methyl donor. S-Adenosylmethionine 165-185 methionine adenosyltransferase 2A Homo sapiens 113-118 10216131-1 1999 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 164-184 methionine adenosyltransferase 2A Homo sapiens 112-117 10216131-1 1999 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes, MAT1A and MAT2A, respectively, that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 186-189 methionine adenosyltransferase 2A Homo sapiens 112-117 9655679-1 1998 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes (MAT1A and MAT2A, respectively) that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 164-184 methionine adenosyltransferase 2A Homo sapiens 112-117 9655679-1 1998 Liver-specific and non-liver-specific methionine adenosyltransferase (MAT) are products of two genes (MAT1A and MAT2A, respectively) that catalyze the formation of S-adenosylmethionine (SAM), the principal methyl donor. S-Adenosylmethionine 186-189 methionine adenosyltransferase 2A Homo sapiens 112-117 9537246-8 1998 SAM level and SAM:S-adenosylhomocysteine (SAH) ratio increased by 50-75% after MAT1A transfection and by an additional 60-80% after MAT2A antisense treatment. S-Adenosylmethionine 0-3 methionine adenosyltransferase 2A Homo sapiens 132-137 34616406-0 2021 MAT2A-Mediated S-Adenosylmethionine Level in CD4+ T Cells Regulates HIV-1 Latent Infection. S-Adenosylmethionine 15-35 methionine adenosyltransferase 2A Homo sapiens 0-5 34780697-3 2021 The initial velocity pattern and results of product inhibition by SAM, phosphate, and pyrophosphate, and dead-end inhibition by the l-Met analog cycloleucine (l-cLeu) suggest that Mat2A follows a strictly ordered kinetic mechanism where ATP binds before l-Met and with SAM released prior to random release of phosphate and pyrophosphate. S-Adenosylmethionine 66-69 methionine adenosyltransferase 2A Homo sapiens 180-185 34668717-1 2021 Human methionine adenosyltransferase MAT2A provides S-adenosyl-l-methionine (AdoMet) for methyl-transfer reactions. S-Adenosylmethionine 52-75 methionine adenosyltransferase 2A Homo sapiens 37-42 34668717-1 2021 Human methionine adenosyltransferase MAT2A provides S-adenosyl-l-methionine (AdoMet) for methyl-transfer reactions. S-Adenosylmethionine 77-83 methionine adenosyltransferase 2A Homo sapiens 37-42 34668717-5 2021 Crystal structures of MAT2A with analogues of AdoMet and pyrophosphate were obtained in the presence of Mg2+, Al3+, and F-. S-Adenosylmethionine 46-52 methionine adenosyltransferase 2A Homo sapiens 22-27 34616406-6 2021 Mechanistically, MAT2A modulates HIV-1 latency through S-Adenosylmethionine (SAM)-mediated one-carbon flux. S-Adenosylmethionine 55-75 methionine adenosyltransferase 2A Homo sapiens 17-22 34616406-6 2021 Mechanistically, MAT2A modulates HIV-1 latency through S-Adenosylmethionine (SAM)-mediated one-carbon flux. S-Adenosylmethionine 77-80 methionine adenosyltransferase 2A Homo sapiens 17-22 35182729-7 2022 Mechanistically, MAT2A mediates the production of S-adenosylmethionine (SAM), which upregulates ACSL3 by increasing the trimethylation of lysine-4 on histone H3 (H3K4me3) at the promoter area, resulting in ferroptosis resistance. S-Adenosylmethionine 50-70 methionine adenosyltransferase 2A Homo sapiens 17-22 34065390-2 2021 Hepatic and extrahepatic tissues methionine adenosyltransferases (MATs) are products of two genes, MAT1A and MAT2A that catalyze the formation of S-adenosylmethionine (SAM), the principal biological methyl donor. S-Adenosylmethionine 146-166 methionine adenosyltransferase 2A Homo sapiens 109-114 34065390-2 2021 Hepatic and extrahepatic tissues methionine adenosyltransferases (MATs) are products of two genes, MAT1A and MAT2A that catalyze the formation of S-adenosylmethionine (SAM), the principal biological methyl donor. S-Adenosylmethionine 168-171 methionine adenosyltransferase 2A Homo sapiens 109-114 35293760-1 2022 Inhibition of the S-adenosyl methionine (SAM)-producing metabolic enzyme, methionine adenosyltransferase 2A (MAT2A), has received significant interest in the field of medicinal chemistry due to its implication as a synthetic lethal target in cancers with the deletion of the methylthioadenosine phosphorylase (MTAP) gene. S-Adenosylmethionine 41-44 methionine adenosyltransferase 2A Homo sapiens 74-107 35293760-1 2022 Inhibition of the S-adenosyl methionine (SAM)-producing metabolic enzyme, methionine adenosyltransferase 2A (MAT2A), has received significant interest in the field of medicinal chemistry due to its implication as a synthetic lethal target in cancers with the deletion of the methylthioadenosine phosphorylase (MTAP) gene. S-Adenosylmethionine 41-44 methionine adenosyltransferase 2A Homo sapiens 109-114 35182729-7 2022 Mechanistically, MAT2A mediates the production of S-adenosylmethionine (SAM), which upregulates ACSL3 by increasing the trimethylation of lysine-4 on histone H3 (H3K4me3) at the promoter area, resulting in ferroptosis resistance. S-Adenosylmethionine 72-75 methionine adenosyltransferase 2A Homo sapiens 17-22 35064691-1 2022 Methionine adenosyltransferase II alpha (MAT2A) is the key enzyme to transform methionine and adenosine-triphosphate (ATP) to S-adenosylmethionine (SAM), a general methyl-group donor in vitro. S-Adenosylmethionine 126-146 methionine adenosyltransferase 2A Homo sapiens 0-39 35064691-1 2022 Methionine adenosyltransferase II alpha (MAT2A) is the key enzyme to transform methionine and adenosine-triphosphate (ATP) to S-adenosylmethionine (SAM), a general methyl-group donor in vitro. S-Adenosylmethionine 126-146 methionine adenosyltransferase 2A Homo sapiens 41-46 35064691-1 2022 Methionine adenosyltransferase II alpha (MAT2A) is the key enzyme to transform methionine and adenosine-triphosphate (ATP) to S-adenosylmethionine (SAM), a general methyl-group donor in vitro. S-Adenosylmethionine 148-151 methionine adenosyltransferase 2A Homo sapiens 0-39 35064691-1 2022 Methionine adenosyltransferase II alpha (MAT2A) is the key enzyme to transform methionine and adenosine-triphosphate (ATP) to S-adenosylmethionine (SAM), a general methyl-group donor in vitro. S-Adenosylmethionine 148-151 methionine adenosyltransferase 2A Homo sapiens 41-46 35159219-1 2022 Alterations of methionine cycle in steatohepatitis, cirrhosis, and hepatocellular carcinoma induce MAT1A decrease and MAT2A increase expressions with the consequent decrease of S-adenosyl-L-methionine (SAM). S-Adenosylmethionine 177-200 methionine adenosyltransferase 2A Homo sapiens 118-123 35159219-1 2022 Alterations of methionine cycle in steatohepatitis, cirrhosis, and hepatocellular carcinoma induce MAT1A decrease and MAT2A increase expressions with the consequent decrease of S-adenosyl-L-methionine (SAM). S-Adenosylmethionine 202-205 methionine adenosyltransferase 2A Homo sapiens 118-123