Pub. Date : 2021 Apr 22
PMID : 33829783
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Fragment screening followed by iterative structure-guided design enabled >10 000-fold improvement in potency of a family of allosteric MAT2A inhibitors that are substrate noncompetitive and inhibit release of the product, S-adenosyl methionine (SAM), from the enzyme"s active site. | S-Adenosylmethionine | methionine adenosyltransferase 2A | Homo sapiens |
2 | Fragment screening followed by iterative structure-guided design enabled >10 000-fold improvement in potency of a family of allosteric MAT2A inhibitors that are substrate noncompetitive and inhibit release of the product, S-adenosyl methionine (SAM), from the enzyme"s active site. | S-Adenosylmethionine | methionine adenosyltransferase 2A | Homo sapiens |