Title : MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage.

Pub. Date : 2021 Feb 8

PMID : 33450196






2 Functional Relationships(s)
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1 We report the characterization of potent MAT2A inhibitors that substantially reduce levels of S-adenosylmethionine (SAM) and demonstrate antiproliferative activity in MTAP-deleted cancer cells and tumors. S-Adenosylmethionine methionine adenosyltransferase 2A Homo sapiens
2 We report the characterization of potent MAT2A inhibitors that substantially reduce levels of S-adenosylmethionine (SAM) and demonstrate antiproliferative activity in MTAP-deleted cancer cells and tumors. S-Adenosylmethionine methionine adenosyltransferase 2A Homo sapiens