Title : MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.

Pub. Date : 2016 Apr 19

PMID : 27068473






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 MAT2A produces the PRMT5 substrate S-adenosylmethionine (SAM), and MAT2A depletion reduces growth and PRMT5 methylation activity selectively in MTAP-deleted cells. S-Adenosylmethionine methionine adenosyltransferase 2A Homo sapiens
2 MAT2A produces the PRMT5 substrate S-adenosylmethionine (SAM), and MAT2A depletion reduces growth and PRMT5 methylation activity selectively in MTAP-deleted cells. S-Adenosylmethionine methionine adenosyltransferase 2A Homo sapiens