Pub. Date : 2012 Nov
PMID : 22879628
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer"s disease. | S-Adenosylmethionine | methionine adenosyltransferase 2A | Homo sapiens |
2 | MAT2A catalyzes the production of S-adenosylmethionine from methionine and ATP, which plays a pivotal role in the methylation of neurotransmitters, DNA, proteins, and lipids. | S-Adenosylmethionine | methionine adenosyltransferase 2A | Homo sapiens |
3 | MAT2A-dependent significant up-regulation of S-adenosylmethionine was also detectable in the knockdown cells compared with controls. | S-Adenosylmethionine | methionine adenosyltransferase 2A | Homo sapiens |