Pub. Date : 2014
PMID : 27508177
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alterations in the methylation of the promoter of methyl adenosyltransferase MAT1A and MAT2A genes in HCC result in decreased S-adenosylmethionine levels, global DNA hypomethylation, and deregulation of signal transduction pathways linked to methionine metabolism and methyl adenosyltransferases activity. | S-Adenosylmethionine | methionine adenosyltransferase 2A | Homo sapiens |
| 2 | Changes in S-adenosylmethionine levels may also depend on MAT1A mRNA destabilization associated with MAT2A mRNA stabilization by specific proteins. | S-Adenosylmethionine | methionine adenosyltransferase 2A | Homo sapiens |