Title : Activation of MAT2A-ACSL3 pathway protects cells from ferroptosis in gastric cancer.

Pub. Date : 2022 Mar

PMID : 35182729






2 Functional Relationships(s)
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Protein Name
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1 Mechanistically, MAT2A mediates the production of S-adenosylmethionine (SAM), which upregulates ACSL3 by increasing the trimethylation of lysine-4 on histone H3 (H3K4me3) at the promoter area, resulting in ferroptosis resistance. S-Adenosylmethionine methionine adenosyltransferase 2A Homo sapiens
2 Mechanistically, MAT2A mediates the production of S-adenosylmethionine (SAM), which upregulates ACSL3 by increasing the trimethylation of lysine-4 on histone H3 (H3K4me3) at the promoter area, resulting in ferroptosis resistance. S-Adenosylmethionine methionine adenosyltransferase 2A Homo sapiens