Polycyclic Aromatic Hydrocarbons

cytochrome P450, family 1, subfamily a, polypeptide 1 ; Mus musculus







39 Article(s)
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Pub. Year
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1 32726451 Polycyclic Aromatic Hydrocarbon-induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP)1A1- and 1A2-Null Mice: Roles of CYP1A1 and CYP1A2. 2020 Oct 1 6
2 30573465 Suppression of Hepatic CYP3A4 Expression and Activity by 3-Methylcholanthrene in Humanized PXR-CAR-CYP3A4/3A7 Mice. 2019 Mar 2
3 30691489 In utero exposure to ultrafine particles promotes placental stress-induced programming of renin-angiotensin system-related elements in the offspring results in altered blood pressure in adult mice. 2019 Jan 28 2
4 26656082 Tumour-promoting activity of polycyclic aromatic hydrocarbons and their oxygenated or nitrated derivatives. 2016 Mar 1
5 27369091 Murine precision-cut lung slices exhibit acute responses following exposure to gasoline direct injection engine emissions. 2016 Oct 15 1
6 24639079 Modulation of aryl hydrocarbon receptor (AHR)-dependent signaling by peroxisome proliferator-activated receptor β/δ (PPARβ/δ) in keratinocytes. 2014 Jul 6
7 23047765 Oral benzo[a]pyrene in Cyp1a1/1b1(-/-) double-knockout mice: Microarray analysis during squamous cell carcinoma formation in preputial gland duct. 2013 May 1 4
8 23846873 Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism. 2013 Oct 1
9 22442665 TLR2 controls intestinal carcinogen detoxication by CYP1A1. 2012 5
10 22066002 Effects of dietary fish oil on the depletion of carcinogenic PAH-DNA adduct levels in the liver of B6C3F1 mouse. 2011 1
11 20117208 Gender-associated modulation of inducible CYP1A1 expression by andrographolide in mouse liver. 2010 Mar 18 2
12 20127859 Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype. 2010 Nov 15 2
13 20732958 Disruption of the gene for CYP1A2, which is expressed primarily in liver, leads to differential regulation of hepatic and pulmonary mouse CYP1A1 expression and augmented human CYP1A1 transcriptional activation in response to 3-methylcholanthrene in vivo. 2010 Nov 2
14 19165387 Deducing in vivo toxicity of combustion-derived nanoparticles from a cell-free oxidative potency assay and metabolic activation of organic compounds. 2009 Jan 4
15 17547212 Aryl hydrocarbon receptor plays a significant role in mediating airborne particulate-induced carcinogenesis in mice. 2007 May 15 1
16 17607366 Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut. 2007 Jul 1
17 16377763 Oral benzo[a]pyrene in Cyp1 knockout mouse lines: CYP1A1 important in detoxication, CYP1B1 metabolism required for immune damage independent of total-body burden and clearance rate. 2006 Apr 2
18 14720319 Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1. 2004 Jan 1
19 14976333 Modulation of carcinogen metabolism and DNA interaction by calcium glucarate in mouse skin. 2004 May 2
20 15102951 Oral exposure to benzo[a]pyrene in the mouse: detoxication by inducible cytochrome P450 is more important than metabolic activation. 2004 May 1
21 12455047 Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo. 2003 Jan 1 3
22 12628579 Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene. 2003 Feb 15 3
23 12785736 Effects of polycyclic aromatic hydrocarbons on liver and lung cytochrome P450s in mice. 2003 May 2
24 11967619 Lung expression of cytochrome P450 1A1 as a possible biomarker of exposure to diesel exhaust particles. 2002 Apr 1
25 9667743 Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene. 1998 Jun 2
26 8706258 Mouse lung tumors exhibit specific Ki-ras mutations following transplacental exposure to 3-methylcholanthrene. 1996 Jul 1
27 8844979 N-nitroso compounds induce changes in carcinogen-metabolizing enzymes. 1996 Sep 10 4
28 7750161 Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice. 1995 Jun 14 3
29 8163516 2,3,7,8-Tetrachlorodibenzo-p-dioxin versus 3-methylcholanthrene: comparative studies of Ah receptor binding, transformation, and induction of CYP1A1. 1994 Apr 22 1
30 1536575 Prostaglandin endoperoxide synthase gene structure: identification of the transcriptional start site and 5'-flanking regulatory sequences. 1992 Mar 1
31 1658612 Ah receptor in mice genetically "nonresponsive" for cytochrome P4501A1 induction: cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. 1991 Nov 1
32 1754392 Induction of the Cyp1a-1 dioxin-responsive enhancer in transgenic mice. 1991 Dec 11 1
33 1910027 Proline is required for transcriptional control of the aromatic hydrocarbon-inducible P(1)450 gene in C57BL/6 mouse monolayer-cultured hepatocytes. 1991 Aug 1
34 2113322 Aryl hydrocarbon hydroxylase activity levels in the hepatic microsomal fraction from MC- or TCDD-treated mice: a comparison between aromatic hydrocarbon responsive and non-responsive strains. 1990 Jun 2
35 2505924 Induction of aryl hydrocarbon hydroxylase and DNA adduct formation in parental and carcinogen transformed C3H/10T1/2 clone 8 cells by benzo[a]pyrene. 1989 May 2
36 6640544 Single-step phototoxic selection procedure for isolating cells that possess aryl hydrocarbon hydroxylase. 1983 Dec 1
37 7120116 Studies on microsomal cytochrome P-450, monooxygenases and epoxide hydrolase in cultured keratinocytes and intact epidermis from BALB/C mice. 1982 Oct 1
38 509418 The stimulation of murine hepatic aryl hydrocarbon hydroxylase activity in vitro by caffeine. 1979 Nov 2
39 1447 Mouse epidermal aryl hydrocarbon hydroxylase. 1976 Feb 2