Title : Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo.

Pub. Date : 2003 Jan 1

PMID : 12455047






3 Functional Relationships(s)
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1 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus
2 In conclusion, these results demonstrate the existence of AHR- and CYP1A1-independent mechanisms of PAH metabolic activation in mouse liver, a phenomenon that may have important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus
3 In conclusion, these results demonstrate the existence of AHR- and CYP1A1-independent mechanisms of PAH metabolic activation in mouse liver, a phenomenon that may have important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus