Title : TLR2 controls intestinal carcinogen detoxication by CYP1A1.

Pub. Date : 2012

PMID : 22442665






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus
2 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus
3 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus
4 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus
5 Here we report that intestinal CYP1A1 is silenced in TLR2-deficient mice, even when under exposure to the carcinogenic PAH benzo[a]pyrene (BaP). Polycyclic Aromatic Hydrocarbons cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus