PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16377763-1 2006 CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis. Polycyclic Aromatic Hydrocarbons 46-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 22066002-13 2011 FO significantly enhanced gene expression of Cyp1a1 in both the high and low dose PAH groups. Polycyclic Aromatic Hydrocarbons 82-85 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 45-51 20732958-10 2010 In conclusion, the results suggest that CYP1A2 plays a pivotal role in the regulation of hepatic and pulmonary CYP1A1 by PAHs, a phenomenon that potentially has important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 121-125 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 111-117 20732958-10 2010 In conclusion, the results suggest that CYP1A2 plays a pivotal role in the regulation of hepatic and pulmonary CYP1A1 by PAHs, a phenomenon that potentially has important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 121-124 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 111-117 19165387-5 2009 On the other hand, a pathway-specific gene expression screen indicated that, for particles rich in polycyclic aromatic hydrocarbon (PAHs), cytochrome P450 1A1 (CYP1A1) enzyme-mediated biotransformation of bio-available organics may generate oxidative stress and thus enhance the in vivo inflammatory response. Polycyclic Aromatic Hydrocarbons 99-130 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 139-158 19165387-5 2009 On the other hand, a pathway-specific gene expression screen indicated that, for particles rich in polycyclic aromatic hydrocarbon (PAHs), cytochrome P450 1A1 (CYP1A1) enzyme-mediated biotransformation of bio-available organics may generate oxidative stress and thus enhance the in vivo inflammatory response. Polycyclic Aromatic Hydrocarbons 99-130 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 160-166 19165387-5 2009 On the other hand, a pathway-specific gene expression screen indicated that, for particles rich in polycyclic aromatic hydrocarbon (PAHs), cytochrome P450 1A1 (CYP1A1) enzyme-mediated biotransformation of bio-available organics may generate oxidative stress and thus enhance the in vivo inflammatory response. Polycyclic Aromatic Hydrocarbons 132-136 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 139-158 19165387-5 2009 On the other hand, a pathway-specific gene expression screen indicated that, for particles rich in polycyclic aromatic hydrocarbon (PAHs), cytochrome P450 1A1 (CYP1A1) enzyme-mediated biotransformation of bio-available organics may generate oxidative stress and thus enhance the in vivo inflammatory response. Polycyclic Aromatic Hydrocarbons 132-136 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 160-166 22442665-1 2012 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 139-171 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 11-39 22442665-1 2012 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 139-171 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 41-47 22442665-1 2012 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 173-176 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 11-39 22442665-1 2012 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 173-176 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 41-47 22442665-4 2012 Here we report that intestinal CYP1A1 is silenced in TLR2-deficient mice, even when under exposure to the carcinogenic PAH benzo[a]pyrene (BaP). Polycyclic Aromatic Hydrocarbons 119-122 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 31-37 20127859-2 2010 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1 and CYP1B1) can both detoxify PAHs and activate them to cancer-causing reactive intermediates. Polycyclic Aromatic Hydrocarbons 74-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-27 20127859-2 2010 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1 and CYP1B1) can both detoxify PAHs and activate them to cancer-causing reactive intermediates. Polycyclic Aromatic Hydrocarbons 74-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 37-43 20117208-1 2010 We previously observed a strong synergistic effect on polycyclic aromatic hydrocarbon (PAH)-induced CYP1A1 expression by andrographolide, a major constituent of an herbal medicine derived from the plant Andrographis paniculata, in mouse hepatocytes in primary culture. Polycyclic Aromatic Hydrocarbons 54-85 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 100-106 20117208-1 2010 We previously observed a strong synergistic effect on polycyclic aromatic hydrocarbon (PAH)-induced CYP1A1 expression by andrographolide, a major constituent of an herbal medicine derived from the plant Andrographis paniculata, in mouse hepatocytes in primary culture. Polycyclic Aromatic Hydrocarbons 87-90 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 100-106 17607366-2 2007 On the other hand, CYP1A1 can also produce highly carcinogenic intermediate metabolites through oxidation of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 109-141 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 19-25 17547212-4 2007 PAH metabolization requires CYP1A1 induction through activation of AhR, and therefore we hypothesized that carcinogenesis due to PAHs in APM would be reduced in AhR-/- mice. Polycyclic Aromatic Hydrocarbons 0-3 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 28-34 16377763-1 2006 CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis. Polycyclic Aromatic Hydrocarbons 80-84 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 12785736-1 2003 Certain polycyclic aromatic hydrocarbons (PAHs) have been reported to induce cytochrome P450 (CYP) 1A1 and 1A2. Polycyclic Aromatic Hydrocarbons 8-40 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 77-110 15102951-1 2004 The cytochrome P450 (CYP1A1) enzyme metabolically activates many polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), to DNA- and protein-binding intermediates that are associated with toxicity, mutagenesis, and carcinogenesis. Polycyclic Aromatic Hydrocarbons 65-97 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 21-27 14976333-12 2004 At the same time, Cag caused a marked inhibition of DMBA-induced aryl hydrocarbon hydroxylase (AHH) activity, an enzyme responsible for the metabolism of PAHs like BP, both in vivo and in vitro. Polycyclic Aromatic Hydrocarbons 154-158 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 65-93 14976333-12 2004 At the same time, Cag caused a marked inhibition of DMBA-induced aryl hydrocarbon hydroxylase (AHH) activity, an enzyme responsible for the metabolism of PAHs like BP, both in vivo and in vitro. Polycyclic Aromatic Hydrocarbons 154-158 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 95-98 14720319-4 2004 Historically, CYP1A1 was believed to be the only enzyme that catalyzes activation of these procarcinogenic PAHs. Polycyclic Aromatic Hydrocarbons 107-111 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 14-20 12785736-1 2003 Certain polycyclic aromatic hydrocarbons (PAHs) have been reported to induce cytochrome P450 (CYP) 1A1 and 1A2. Polycyclic Aromatic Hydrocarbons 42-46 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 77-110 12628579-1 2003 Tissue-specific induction of mRNA of cytochrome P450 (P450 or CYP) 1A1 and 1B1 by polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) was investigated in wild and arylhydrocarbon receptor (AhR)-deficient C57BL/6J mice. Polycyclic Aromatic Hydrocarbons 82-114 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 54-78 12628579-1 2003 Tissue-specific induction of mRNA of cytochrome P450 (P450 or CYP) 1A1 and 1B1 by polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) was investigated in wild and arylhydrocarbon receptor (AhR)-deficient C57BL/6J mice. Polycyclic Aromatic Hydrocarbons 116-120 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 54-78 12628579-9 2003 These results suggest that CYP1A1 and CYP1B1 are differentially regulated in their expression in extrahepatic organs of mice and could be induced by PAHs and PCBs with different extents of induction depending on the inducers used and the organs examined in AhR(+/+) mice. Polycyclic Aromatic Hydrocarbons 149-153 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 27-33 11967619-2 2002 Cytochrome P450 (Cyp) 1A1 can be induced by several kinds of PAH and produce ROS. Polycyclic Aromatic Hydrocarbons 61-64 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-25 12455047-3 2003 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 108-112 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 84-90 12455047-10 2003 In conclusion, these results demonstrate the existence of AHR- and CYP1A1-independent mechanisms of PAH metabolic activation in mouse liver, a phenomenon that may have important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 100-103 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 67-73 12455047-10 2003 In conclusion, these results demonstrate the existence of AHR- and CYP1A1-independent mechanisms of PAH metabolic activation in mouse liver, a phenomenon that may have important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 195-198 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 67-73 9667743-2 1998 The present study utilized a pharmacogenetic mouse model to assess the role of cytochrome P4501A1 (Cyp1a1) in modulating genetic damage to oncogenic and tumor suppressor loci following in utero exposure to the polycyclic aromatic hydrocarbon, 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 210-241 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 79-97 9667743-2 1998 The present study utilized a pharmacogenetic mouse model to assess the role of cytochrome P4501A1 (Cyp1a1) in modulating genetic damage to oncogenic and tumor suppressor loci following in utero exposure to the polycyclic aromatic hydrocarbon, 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 210-241 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 99-105 8844979-1 1996 The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes. Polycyclic Aromatic Hydrocarbons 41-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 191-218 8844979-1 1996 The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes. Polycyclic Aromatic Hydrocarbons 41-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 220-223 8844979-1 1996 The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes. Polycyclic Aromatic Hydrocarbons 75-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 191-218 8844979-1 1996 The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes. Polycyclic Aromatic Hydrocarbons 75-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 220-223 1910027-11 1991 Our observations suggest that induction of AHH after treatment with polycyclic aromatic hydrocarbon is dependent on proline-related metabolism which influences the transcriptional process of P(1)450 gene expression. Polycyclic Aromatic Hydrocarbons 68-99 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 43-46 8706258-1 1996 A pharmacogenetic mouse model was utilized to determine the role of Cyp1a1 expression on the formation of Ki-ras mutations in lung tumors following transplacental exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 209-213 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 68-74 1754392-1 1991 Cyp1a-1, whose product, aryl hydrocarbon hydroxylase, assists in detoxification of polycyclic aromatic hydrocarbons, is the best characterized of the murine cytochrome P450 genes. Polycyclic Aromatic Hydrocarbons 83-115 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-7 7750161-0 1995 Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice. Polycyclic Aromatic Hydrocarbons 79-112 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 13-20 7750161-1 1995 The potential non-additive interactions of polynuclear aromatic hydrocarbon (PAH) mixtures as inducers of Cyp1a-1 and Cyp1a-2 gene expression were investigated in B6C3F1 mice using a reconstituted PAH mixture. Polycyclic Aromatic Hydrocarbons 77-80 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 106-113 7750161-5 1995 The > or = 4-ring PAH fraction and reconstituted mixture induced hepatic microsomal ethoxyresorufin O-deethylase (EROD) activity and Cyp1a-1 mRNA levels, whereas the 2- and 3-ring PAHs were only weakly active. Polycyclic Aromatic Hydrocarbons 21-24 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 136-143 8163516-1 1994 Halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons such as 3-methylcholanthrene (MC) cause transcriptional activation of the CYP1A1 gene via their interaction with the aromatic hydrocarbon (Ah) receptor. Polycyclic Aromatic Hydrocarbons 89-121 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 196-202 1536575-10 1992 An unexpected finding was the presence at position -403 to -385 of a putative dioxin responsive element, a sequence found to be responsible for the induction of transcription of the cytochrome P450IA1 gene (CYPIA1) and other genes involved in detoxification/activation of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 272-304 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 207-213 1658612-1 1991 The aromatic hydrocarbon (Ah) receptor mediates induction of cytochrome P4501A1 and associated aryl hydrocarbon hydroxylase (AHH) activity in tissues or cells exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 170-202 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 61-79 2113322-1 1990 The effects of in vivo administration of polycyclic aromatic hydrocarbons on the levels of aryl hydrocarbon hydroxylase (AHH) activity in aromatic hydrocarbon (Ah) responsive and non-responsive strains of mice were studied using the hepatic microsomal fraction. Polycyclic Aromatic Hydrocarbons 41-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 91-119 2113322-1 1990 The effects of in vivo administration of polycyclic aromatic hydrocarbons on the levels of aryl hydrocarbon hydroxylase (AHH) activity in aromatic hydrocarbon (Ah) responsive and non-responsive strains of mice were studied using the hepatic microsomal fraction. Polycyclic Aromatic Hydrocarbons 41-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 121-124 509418-6 1979 Thus, the inhibition by caffeine of the binding of polycyclic aromatic hydrocarbons (PAH) to DNA may be related to its effect on AHH. Polycyclic Aromatic Hydrocarbons 51-83 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 129-132 2505924-1 1989 C3H/10T1/2 clone 8 (10T1/2) cells possess aryl hydrocarbon hydroxylase (AHH) activity capable of metabolizing polycyclic aromatic hydrocarbons to ultimate carcinogenic forms. Polycyclic Aromatic Hydrocarbons 110-142 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 42-70 2505924-1 1989 C3H/10T1/2 clone 8 (10T1/2) cells possess aryl hydrocarbon hydroxylase (AHH) activity capable of metabolizing polycyclic aromatic hydrocarbons to ultimate carcinogenic forms. Polycyclic Aromatic Hydrocarbons 110-142 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 72-75 6640544-2 1983 Twenty polycyclic aromatic hydrocarbons were screened for phototoxicity and toxicity in the absence of light in the mouse hepatoma line Hepa1c1c7, which has high inducible aryl hydrocarbon hydroxylase (AHH) activity, and in AHH-deficient mutants derived from this line. Polycyclic Aromatic Hydrocarbons 7-39 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 202-205 7120116-3 1982 In vitro treatment of the cells or in vivo application to the skin of animals with the polycyclic aromatic hydrocarbons benz(a)anthracene (BA) or benzo(a)pyrene resulted in significant induction of AHH and 7-ED activities. Polycyclic Aromatic Hydrocarbons 87-119 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 198-201 509418-6 1979 Thus, the inhibition by caffeine of the binding of polycyclic aromatic hydrocarbons (PAH) to DNA may be related to its effect on AHH. Polycyclic Aromatic Hydrocarbons 85-88 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 129-132 1447-1 1976 Mouse skin contains a NADPH-dependent, aryl hydrocarbon hydroxylase (AHH), which is inducible by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 97-129 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 39-67 1447-1 1976 Mouse skin contains a NADPH-dependent, aryl hydrocarbon hydroxylase (AHH), which is inducible by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 97-129 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 69-72 30573465-1 2019 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that activate the aryl hydrocarbon receptor, thereby triggering a range of biologic responses, exemplified by the induction of CYP1A1 PAHs can also regulate the expression of members of the CYP3A subfamily, with reports of mainly suppressive effects on mouse hepatic Cyp3a11 expression, but paradoxically both inductive and suppressive effects on human hepatic CYP3A4 expression. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 196-202 32726451-0 2020 Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 74-99 32726451-0 2020 Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 129-135 32726451-0 2020 Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 33-36 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 74-99 32726451-6 2020 In this investigation, we tested the hypothesis that mice lacking the genes for Cyp1a1 or Cyp1a2 will display altered susceptibilities to PAH-induced pulmonary carcinogenesis. Polycyclic Aromatic Hydrocarbons 138-141 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 80-86 32726451-9 2020 Cyp1a1-/- and Cyp1a2-/- mice treated with PAHs displayed a compensatory pattern, where knocking out one Cyp1a gene led to increased expression of the other. Polycyclic Aromatic Hydrocarbons 42-46 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 32726451-12 2020 In conclusion, Cyp1a1-/- mice were less susceptible to PAH-induced pulmonary carcinogenesis, while Cyp1a2-/- mice were more susceptible. Polycyclic Aromatic Hydrocarbons 55-58 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 15-21 30573465-1 2019 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that activate the aryl hydrocarbon receptor, thereby triggering a range of biologic responses, exemplified by the induction of CYP1A1 PAHs can also regulate the expression of members of the CYP3A subfamily, with reports of mainly suppressive effects on mouse hepatic Cyp3a11 expression, but paradoxically both inductive and suppressive effects on human hepatic CYP3A4 expression. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 196-202 27369091-9 2016 Exposure to GDI engine exhaust upregulated genes involved in PAH metabolism, including Cyp1a1 (2.71, SE=0.22), and Cyp1b1 (3.24, SE=0.12) compared to HEPA filtered air (p<0.05). Polycyclic Aromatic Hydrocarbons 61-64 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 87-93 30691489-8 2019 Polycyclic aromatic hydrocarbon (PAH) biotransformation (CYP1A1 and NQO1 (NAD(P)H dehydrogenase (quinone)1)) enzymes, inflammation and oxidative stress in placentas and fetuses were measured. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 57-63 30691489-8 2019 Polycyclic aromatic hydrocarbon (PAH) biotransformation (CYP1A1 and NQO1 (NAD(P)H dehydrogenase (quinone)1)) enzymes, inflammation and oxidative stress in placentas and fetuses were measured. Polycyclic Aromatic Hydrocarbons 33-36 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 57-63 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 84-88 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 37-43 23846873-1 2013 The aryl hydrocarbon receptor (AHR)-dependent induction of cytochromes P450 (P450) such as CYP1A1 by 3-methylcholanthrene (MC) and related polycyclic aromatic hydrocarbons is well characterized. Polycyclic Aromatic Hydrocarbons 139-171 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 91-97 26656082-5 2016 In addition, clear mRNA expression of CYP1A1, which is associated with aryl hydrocarbon receptor (AhR)-mediated activation, was observed following the exposure of cells to two PAHs (B[k]FA and B[b]FA) and three oxy-PAHs (1,2-naphthoquinone, 11H-benzo[b]fluoren-11-one and BPO). Polycyclic Aromatic Hydrocarbons 176-180 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 38-44 24639079-2 2014 Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 63-81 24639079-2 2014 Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 83-89 24639079-2 2014 Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. Polycyclic Aromatic Hydrocarbons 34-37 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 63-81 24639079-2 2014 Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. Polycyclic Aromatic Hydrocarbons 34-37 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 83-89 24639079-4 2014 Pparbeta/delta-null keratinocytes exhibited decreased AHR occupancy and histone acetylation on the Cyp1a1 promoter in response to a PAH compared with wild-type keratinocytes. Polycyclic Aromatic Hydrocarbons 132-135 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 99-105 24639079-9 2014 The mechanisms underlying this PPARbeta/delta-dependent reduction of AHR signaling by PAH are not due to alterations in the expression of AHR auxiliary proteins, ligand binding or AHR nuclear translocation between genotypes, but are likely influenced by PPARbeta/delta-dependent demethylation of AHR target gene promoters including Cyp1a1 that reduces AHR accessibility as shown by reduced promoter occupancy. Polycyclic Aromatic Hydrocarbons 86-89 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 332-338 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 84-88 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-27 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 204-208 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-27 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 204-208 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 37-43