Title : Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene.

Pub. Date : 1998 Jun

PMID : 9667743






2 Functional Relationships(s)
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1 The present study utilized a pharmacogenetic mouse model to assess the role of cytochrome P4501A1 (Cyp1a1) in modulating genetic damage to oncogenic and tumor suppressor loci following in utero exposure to the polycyclic aromatic hydrocarbon, 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus
2 The present study utilized a pharmacogenetic mouse model to assess the role of cytochrome P4501A1 (Cyp1a1) in modulating genetic damage to oncogenic and tumor suppressor loci following in utero exposure to the polycyclic aromatic hydrocarbon, 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus