Pub. Date : 2020 Oct 1
PMID : 32726451
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 3 | Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 4 | In this investigation, we tested the hypothesis that mice lacking the genes for Cyp1a1 or Cyp1a2 will display altered susceptibilities to PAH-induced pulmonary carcinogenesis. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 5 | Cyp1a1-/- and Cyp1a2-/- mice treated with PAHs displayed a compensatory pattern, where knocking out one Cyp1a gene led to increased expression of the other. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 6 | In conclusion, Cyp1a1-/- mice were less susceptible to PAH-induced pulmonary carcinogenesis, while Cyp1a2-/- mice were more susceptible. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |