Pub. Date : 2014 Jul
PMID : 24639079
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 2 | Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 3 | Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 4 | Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 5 | Pparbeta/delta-null keratinocytes exhibited decreased AHR occupancy and histone acetylation on the Cyp1a1 promoter in response to a PAH compared with wild-type keratinocytes. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 6 | The mechanisms underlying this PPARbeta/delta-dependent reduction of AHR signaling by PAH are not due to alterations in the expression of AHR auxiliary proteins, ligand binding or AHR nuclear translocation between genotypes, but are likely influenced by PPARbeta/delta-dependent demethylation of AHR target gene promoters including Cyp1a1 that reduces AHR accessibility as shown by reduced promoter occupancy. | Polycyclic Aromatic Hydrocarbons | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |