| 401 |
11285263 | Partial reconstitution of photoreceptor cGMP phosphodiesterase characteristics in cGMP phosphodiesterase-5. | 2001 Jun 15 |
4 |
| 402 |
11289569 | Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor: urologic and cardiovascular implications. | 2001 Feb |
3 |
| 403 |
11358813 | Exisulind, a novel proapoptotic drug, inhibits rat urinary bladder tumorigenesis. | 2001 May 15 |
1 |
| 404 |
11557915 | The effect of sildenafil on nitric oxide-mediated vasodilation in healthy men. | 2001 Sep |
2 |
| 405 |
11597484 | Synthesis and phosphodiesterase inhibitory activity of new sildenafil analogues containing a carboxylic acid group in the 5'-sulfonamide moiety of a phenyl ring. | 2001 Nov |
1 |
| 406 |
11602184 | The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3. | 2001 Oct |
2 |
| 407 |
11669467 | Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor. | 2001 Sep 28 |
2 |
| 408 |
11696008 | Activation of phosphodiesterase 5 and inhibition of guanylate cyclase by cGMP-dependent protein kinase in smooth muscle. | 2001 Nov 15 |
2 |
| 409 |
11890515 | The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. | 2001 Oct |
1 |
| 410 |
10654914 | Effects of sildenafil on cAMP and cGMP levels in isolated human cavernous and cardiac tissue. | 2000 Jan |
2 |
| 411 |
10679255 | Expression of three isoforms of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum. | 2000 Feb 16 |
2 |
| 412 |
10679826 | Expression and regulation of the cGMP-binding, cGMP-specific phosphodiesterase (PDE5) in human colonic epithelial cells: role in the induction of cellular refractoriness to the heat-stable enterotoxin peptide. | 2000 Feb |
10 |
| 413 |
10725373 | Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. | 2000 Mar 28 |
1 |
| 414 |
10769052 | Immunohistochemical localization of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in rat tissues. | 2000 May |
3 |
| 415 |
10910034 | Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. | 2000 Jul 1 |
2 |
| 416 |
10913932 | Erectile dysfunction: from biochemical pharmacology to advances in medical therapy. | 2000 Aug |
1 |
| 417 |
10924156 | Histidine-607 and histidine-643 provide important interactions for metal support of catalysis in phosphodiesterase-5. | 2000 Aug 8 |
4 |
| 418 |
10977127 | Functional identification of phosphodiesterase activity in human trabecular meshwork cells. | 2000 Aug |
1 |
| 419 |
11137498 | Sex and the patient with cardiovascular risk factors: focus on sildenafil. | 2000 Dec 18 |
4 |
| 420 |
11152621 | Cross-regulation of intracellular cGMP and cAMP in cultured human corpus cavernosum smooth muscle cells. | 2000 Jul |
2 |
| 421 |
11228938 | Physiological significance of nitrergic transmission in human penile erection. | 2000 Mar |
2 |
| 422 |
9922221 | Identification and function of cyclic nucleotide phosphodiesterase isoenzymes in airway epithelial cells. | 1999 Feb |
1 |
| 423 |
10078537 | Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. | 1999 Mar 4 |
2 |
| 424 |
10078538 | Effects of sildenafil citrate on human hemodynamics. | 1999 Mar 4 |
2 |
| 425 |
10078539 | Sildenafil citrate and blood-pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist. | 1999 Mar 4 |
2 |
| 426 |
10385692 | Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds. | 1999 Jul |
7 |
| 427 |
10506154 | Studies of the molecular mechanism of discrimination between cGMP and cAMP in the allosteric sites of the cGMP-binding cGMP-specific phosphodiesterase (PDE5). | 1999 Oct 8 |
5 |
| 428 |
10574925 | Expression of an active, monomeric catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5). | 1999 Dec 3 |
3 |
| 429 |
12567500 | [Mode of action of sildenafil]. | 1999 Dec |
3 |
| 430 |
12973386 | Sildenafil: a new oral therapy for erectile dysfunction. | 1999 Mar |
1 |
| 431 |
9445376 | Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation. | 1998 Feb 1 |
7 |
| 432 |
9486247 | ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells. | 1998 Feb |
6 |
| 433 |
9624146 | Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. | 1998 Jun 19 |
2 |
| 434 |
9642111 | Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5). | 1998 Jun 18 |
3 |
| 435 |
9716380 | Expression, structure and chromosomal localization of the human cGMP-binding cGMP-specific phosphodiesterase PDE5A gene. | 1998 Jul 15 |
4 |
| 436 |
9765278 | Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes. | 1998 Oct 16 |
2 |
| 437 |
9817684 | Effects of dipyridamole and inhaled nitric oxide in pediatric patients with pulmonary hypertension. | 1998 Nov |
2 |
| 438 |
9916601 | Safety and efficacy of sildenafil citrate in the treatment of male erectile dysfunction. | 1998 Nov-Dec |
4 |
| 439 |
9218482 | The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase. | 1997 Jul 18 |
1 |
| 440 |
9115850 | Characterization of the isoenzymes of cyclic nucleotide phosphodiesterase in human platelets and the effects of E4021. | 1996 Dec |
1 |
| 441 |
7653611 | Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary vasodilation in the ovine fetus. | 1995 Aug |
1 |
| 442 |
7870041 | Characterization of cyclic nucleotide phosphodiesterases with cyclic GMP analogs: topology of the catalytic domains. | 1995 Feb |
1 |
| 443 |
8226796 | The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone. | 1993 Oct 25 |
2 |