Pub. Date : 1999 Jul
PMID : 10385692
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus cavernosum of the penis. | Cyclic GMP | phosphodiesterase 5A | Homo sapiens |
| 2 | The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus cavernosum of the penis. | Cyclic GMP | phosphodiesterase 5A | Homo sapiens |
| 3 | The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus cavernosum of the penis. | Cyclic GMP | phosphodiesterase 5A | Homo sapiens |
| 4 | The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus cavernosum of the penis. | Cyclic GMP | phosphodiesterase 5A | Homo sapiens |
| 5 | Sildenafil (Viagra), a specific PDE5 inhibitor, promotes penile erection by blocking the activity of PDE5, which causes cGMP to accumulate in the corpus cavernosum. | Cyclic GMP | phosphodiesterase 5A | Homo sapiens |
| 6 | In the present study, sildenafil, like other PDE5 inhibitors, stimulates cGMP binding to the allosteric sites of PDE5 by interacting at the catalytic site of this enzyme, but the drug does not compete with cGMP for binding at the allosteric sites. | Cyclic GMP | phosphodiesterase 5A | Homo sapiens |
| 7 | The affinity of each of these inhibitors for PDE5 is much higher than that of cGMP itself (Km = 2000 nM). | Cyclic GMP | phosphodiesterase 5A | Homo sapiens |