Title : Studies of the molecular mechanism of discrimination between cGMP and cAMP in the allosteric sites of the cGMP-binding cGMP-specific phosphodiesterase (PDE5).

Pub. Date : 1999 Oct 8

PMID : 10506154






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Studies of the molecular mechanism of discrimination between cGMP and cAMP in the allosteric sites of the cGMP-binding cGMP-specific phosphodiesterase (PDE5). Cyclic GMP phosphodiesterase 5A Homo sapiens
2 Studies of the molecular mechanism of discrimination between cGMP and cAMP in the allosteric sites of the cGMP-binding cGMP-specific phosphodiesterase (PDE5). Cyclic GMP phosphodiesterase 5A Homo sapiens
3 The regulatory domain of the cGMP-binding cGMP-specific 3":5"-cyclic nucleotide phosphodiesterase (PDE5) contains two homologous segments of amino acid sequence that encode allosteric cyclic nucleotide-binding sites, referred to as site a and site b, which are highly selective for cGMP over cAMP. Cyclic GMP phosphodiesterase 5A Homo sapiens
4 The total cGMP binding by PDE5 was unchanged by variation in pH, but the relative affinity for cGMP versus cAMP progressively decreased as the pH was lowered. Cyclic GMP phosphodiesterase 5A Homo sapiens
5 The total cGMP binding by PDE5 was unchanged by variation in pH, but the relative affinity for cGMP versus cAMP progressively decreased as the pH was lowered. Cyclic GMP phosphodiesterase 5A Homo sapiens