Title : Cross-regulation of intracellular cGMP and cAMP in cultured human corpus cavernosum smooth muscle cells.

Pub. Date : 2000 Jul

PMID : 11152621






2 Functional Relationships(s)
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1 Kinetic analyses of cGMP hydrolysis by PDE 5 showed that high concentrations of cAMP reversibly inhibited the enzyme with a K(i) of 258 +/- 54 microM. Cyclic GMP phosphodiesterase 5A Homo sapiens
2 Our data suggest that cAMP up-regulates intracellular levels of cGMP, in part, by inhibition of PDE 5. Cyclic GMP phosphodiesterase 5A Homo sapiens